Human Gene LRRC37A2 (uc002ikn.1) Description and Page Index
  Description: Homo sapiens leucine rich repeat containing 37, member A2 (LRRC37A2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:44,590,076-44,633,014 Size: 42,939 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr17:44,590,079-44,632,945 Size: 42,867 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:44,590,076-44,633,014)mRNA (may differ from genome)Protein (1700 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: L37A2_HUMAN
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 37A2; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Belongs to the LRRC37A family.
SIMILARITY: Contains 10 LRR (leucine-rich) repeats.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.96 RPKM in Testis
Total median expression: 17.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -7.9069-0.114 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR015753 - PRP

Pfam Domains:
PF13306 - Leucine rich repeats (6 copies)
PF13516 - Leucine Rich repeat
PF13855 - Leucine rich repeat
PF14914 - LRRC37A/B like protein 1 C-terminal domain
PF15779 - Leucine-rich repeat-containing protein 37 family

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on A6NM11
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK126994 - Homo sapiens cDNA FLJ45049 fis, clone BRAWH3022347.
BC040501 - Homo sapiens leucine rich repeat containing 37A, mRNA (cDNA clone MGC:33880 IMAGE:5295808), complete cds.
CR749232 - Homo sapiens mRNA; cDNA DKFZp686N1231 (from clone DKFZp686N1231).
BC172235 - Synthetic construct Homo sapiens clone IMAGE:100068929, MGC:198940 leucine rich repeat containing 37, member A2 (LRRC37A2) mRNA, encodes complete protein.
BC172554 - Synthetic construct Homo sapiens clone IMAGE:100069248, MGC:199259 leucine rich repeat containing 37, member A2 (LRRC37A2) mRNA, encodes complete protein.
DQ573558 - Homo sapiens piRNA piR-41670, complete sequence.
DQ572749 - Homo sapiens piRNA piR-40861, complete sequence.
DQ592824 - Homo sapiens piRNA piR-59936, complete sequence.
AY386262 - Homo sapiens c114 SLIT-like testicular protein mRNA, complete cds.
JD400493 - Sequence 381517 from Patent EP1572962.
BC144427 - Homo sapiens leucine rich repeat containing 37, member A2, mRNA (cDNA clone IMAGE:9052948), partial cds.
BC144428 - Homo sapiens leucine rich repeat containing 37, member A2, mRNA (cDNA clone IMAGE:9052949), partial cds.
JD489344 - Sequence 470368 from Patent EP1572962.
DQ579943 - Homo sapiens piRNA piR-48055, complete sequence.
JD516450 - Sequence 497474 from Patent EP1572962.
JD368101 - Sequence 349125 from Patent EP1572962.
DQ573673 - Homo sapiens piRNA piR-41785, complete sequence.
JQ790592 - Homo sapiens isolate G248_8 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790625 - Homo sapiens isolate hcerebellumE8 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790563 - Homo sapiens isolate G248_6 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790584 - Homo sapiens isolate G248_18 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790597 - Homo sapiens isolate G248_39 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790599 - Homo sapiens isolate G248_22 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790610 - Homo sapiens isolate hcerebellumC12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790633 - Homo sapiens isolate hcerebellumG6a leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790661 - Homo sapiens isolate hcerebellumF1 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790669 - Homo sapiens isolate hcerebellumB11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790688 - Homo sapiens isolate HeLa5 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790691 - Homo sapiens isolate HeLa24 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790698 - Homo sapiens isolate HeLa32 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790721 - Homo sapiens isolate HeLa35 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JD302592 - Sequence 283616 from Patent EP1572962.
JQ790726 - Homo sapiens isolate htestis_A07-A01 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790730 - Homo sapiens isolate htestis_E01-E07 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790732 - Homo sapiens isolate htestis_G01-G07 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790742 - Homo sapiens isolate htestis_B03-B09 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790762 - Homo sapiens isolate htestis_H05-H11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790752 - Homo sapiens isolate htestis_E04-E10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790727 - Homo sapiens isolate htestis_B07-B01 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790728 - Homo sapiens isolate htestis_C01-C07 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790729 - Homo sapiens isolate htestis_D07-D01 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790734 - Homo sapiens isolate htestis_A02-A08 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790738 - Homo sapiens isolate htestis_F02-F08 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790739 - Homo sapiens isolate htestis_G02-G08 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790740 - Homo sapiens isolate htestis_H02-H08 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790741 - Homo sapiens isolate htestis_A03-A09 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790743 - Homo sapiens isolate htestis_C03-C09 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790745 - Homo sapiens isolate htestis_E03-09 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790748 - Homo sapiens isolate htestis_A04-A10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790749 - Homo sapiens isolate htestis_B04-B10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790750 - Homo sapiens isolate htestis_C04-C10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790755 - Homo sapiens isolate htestis_H04-H10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790756 - Homo sapiens isolate htestis_A05-A11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790757 - Homo sapiens isolate htestis_B05-B11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790758 - Homo sapiens isolate htestis_C05-C11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790759 - Homo sapiens isolate htestis_D05-D11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790763 - Homo sapiens isolate htestis_A06-A12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790764 - Homo sapiens isolate htestis_B06-B12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790765 - Homo sapiens isolate htestis_C06-C12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790735 - Homo sapiens isolate htestis_C02-C08 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790570 - Homo sapiens isolate G248_28 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790665 - Homo sapiens isolate hcerebellumA3 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790704 - Homo sapiens isolate HeLa2 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790562 - Homo sapiens isolate G248_5 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790564 - Homo sapiens isolate G248_7 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790566 - Homo sapiens isolate G248_11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790568 - Homo sapiens isolate G248_21 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790571 - Homo sapiens isolate G248_30 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790572 - Homo sapiens isolate G248_31 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790573 - Homo sapiens isolate G248_33 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790576 - Homo sapiens isolate G248_37 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790577 - Homo sapiens isolate G248_40 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790578 - Homo sapiens isolate G248_41 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790579 - Homo sapiens isolate G248_42 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790580 - Homo sapiens isolate G248_44 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790581 - Homo sapiens isolate G248_45 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790590 - Homo sapiens isolate G248_15 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790591 - Homo sapiens isolate G248_3 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790593 - Homo sapiens isolate G248_19 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790595 - Homo sapiens isolate G248_26 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790596 - Homo sapiens isolate G248_32 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790598 - Homo sapiens isolate G248_4 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790606 - Homo sapiens isolate hcerebellumB12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790607 - Homo sapiens isolate hcerebellumC2 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790613 - Homo sapiens isolate hcerebellumE12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790617 - Homo sapiens isolate hcerebellumG1 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790626 - Homo sapiens isolate hcerebellumE10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790628 - Homo sapiens isolate hcerebellumA10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790629 - Homo sapiens isolate hcerebellumA4 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790634 - Homo sapiens isolate hcerebellumB2 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790636 - Homo sapiens isolate hcerebellumC4 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790637 - Homo sapiens isolate hcerebellumC7 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790641 - Homo sapiens isolate hcerebellumF10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790642 - Homo sapiens isolate hcerebellumG2 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790660 - Homo sapiens isolate hcerebellumD7 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790662 - Homo sapiens isolate hcerebellumG3 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790663 - Homo sapiens isolate hcerebellumH1 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790674 - Homo sapiens isolate hcerebellumD9 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790675 - Homo sapiens isolate hcerebellumE4 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790677 - Homo sapiens isolate hcerebellumH3 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790678 - Homo sapiens isolate hcerebellumH11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790690 - Homo sapiens isolate HeLa22 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790692 - Homo sapiens isolate HeLa25 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790693 - Homo sapiens isolate HeLa26 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790694 - Homo sapiens isolate HeLa27 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790699 - Homo sapiens isolate HeLa33 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790700 - Homo sapiens isolate HeLa37 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790702 - Homo sapiens isolate HeLa8 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790705 - Homo sapiens isolate HeLa11 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790706 - Homo sapiens isolate HeLa18 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790708 - Homo sapiens isolate HeLa47 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790710 - Homo sapiens isolate HeLa10 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790713 - Homo sapiens isolate HeLa30 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790714 - Homo sapiens isolate HeLa6 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790715 - Homo sapiens isolate HeLa15 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790716 - Homo sapiens isolate HeLa17 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790718 - Homo sapiens isolate HeLa44 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790719 - Homo sapiens isolate HeLa7 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790720 - Homo sapiens isolate HeLa16 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790723 - Homo sapiens isolate HeLa12 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790724 - Homo sapiens isolate HeLa34 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790725 - Homo sapiens isolate HeLa38 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790744 - Homo sapiens isolate htestis_D03-D09 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790664 - Homo sapiens isolate hcerebellumH5 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790680 - Homo sapiens isolate hcerebellumG6b leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JQ790703 - Homo sapiens isolate HeLa13 leucine rich repeat-containing 37 (LRRC37) mRNA, partial sequence.
JD311128 - Sequence 292152 from Patent EP1572962.
DQ593902 - Homo sapiens piRNA piR-34014, complete sequence.
JD434081 - Sequence 415105 from Patent EP1572962.
JD083633 - Sequence 64657 from Patent EP1572962.
AK091733 - Homo sapiens cDNA FLJ34414 fis, clone HEART2003168, highly similar to Homo sapiens c114 SLIT-like testicular protein (LOC474170), mRNA.
AX747150 - Sequence 675 from Patent EP1308459.
BC088375 - Homo sapiens c114 SLIT-like testicular protein, mRNA (cDNA clone IMAGE:6193137).
DQ599778 - Homo sapiens piRNA piR-37844, complete sequence.
JD178227 - Sequence 159251 from Patent EP1572962.
JD103095 - Sequence 84119 from Patent EP1572962.
JD037451 - Sequence 18475 from Patent EP1572962.
JD308620 - Sequence 289644 from Patent EP1572962.
JD308621 - Sequence 289645 from Patent EP1572962.
JD408232 - Sequence 389256 from Patent EP1572962.
JD481948 - Sequence 462972 from Patent EP1572962.
JD321795 - Sequence 302819 from Patent EP1572962.
DQ600094 - Homo sapiens piRNA piR-38160, complete sequence.
DQ596956 - Homo sapiens piRNA piR-35022, complete sequence.
DQ588570 - Homo sapiens piRNA piR-55682, complete sequence.
JD137393 - Sequence 118417 from Patent EP1572962.
DQ575353 - Homo sapiens piRNA piR-43465, complete sequence.
JD060203 - Sequence 41227 from Patent EP1572962.
JD271976 - Sequence 253000 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NM11, L37A2_HUMAN, NM_001006607, NP_001006608
UCSC ID: uc002ikn.1
RefSeq Accession: NM_001006607
Protein: A6NM11 (aka L37A2_HUMAN)
CCDS: CCDS42353.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001006607.2
exon count: 14CDS single in 3' UTR: no RNA size: 5175
ORF size: 5103CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 9541.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.