Human Gene ZNF322 (uc021yny.1) Description and Page Index
  Description: Homo sapiens zinc finger protein 322 (ZNF322), transcript variant 3, mRNA.
RefSeq Summary (NM_001242798): ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:26,634,611-26,659,980 Size: 25,370 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr6:26,637,573-26,638,781 Size: 1,209 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:26,634,611-26,659,980)mRNA (may differ from genome)Protein (402 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN322_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 322; AltName: Full=Zinc finger protein 322A; AltName: Full=Zinc finger protein 388; AltName: Full=Zinc finger protein 489;
FUNCTION: Involved in transcriptional regulation as an activator.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart and skeletal muscle.
DEVELOPMENTAL STAGE: Expressed in embryo as early as the 11th week of gestation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.70 RPKM in Bladder
Total median expression: 74.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -209.06576-0.363 Picture PostScript Text
3' UTR -829.682962-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q6U7Q0
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0035326 enhancer binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:1902459 positive regulation of stem cell population maintenance

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  DQ786258 - Homo sapiens clone HLS_IMAGE_282884 mRNA sequence.
BC058829 - Homo sapiens HLA complex group 12, mRNA (cDNA clone IMAGE:4775484).
BC107578 - Homo sapiens cDNA clone IMAGE:4334226.
BC070371 - Homo sapiens HLA complex group 12, mRNA (cDNA clone IMAGE:4657554).
AK027046 - Homo sapiens cDNA: FLJ23393 fis, clone HEP17447.
AY376736 - Homo sapiens zinc finger protein 322 (ZNF322) mRNA, complete cds.
JD174867 - Sequence 155891 from Patent EP1572962.
JD561653 - Sequence 542677 from Patent EP1572962.
BC050425 - Homo sapiens zinc finger protein 322A, mRNA (cDNA clone MGC:54129 IMAGE:6473688), complete cds.
JD278726 - Sequence 259750 from Patent EP1572962.
JD270388 - Sequence 251412 from Patent EP1572962.
JD064186 - Sequence 45210 from Patent EP1572962.
BC119669 - Homo sapiens zinc finger protein 322A, mRNA (cDNA clone MGC:149551 IMAGE:40116184), complete cds.
BC139750 - Homo sapiens cDNA clone IMAGE:40116185, containing frame-shift errors.
JD271457 - Sequence 252481 from Patent EP1572962.
AK290038 - Homo sapiens cDNA FLJ76346 complete cds, highly similar to Homo sapiens zinc finger protein 322A (ZNF322A), mRNA.
BC074772 - Homo sapiens zinc finger protein 322A, mRNA (cDNA clone IMAGE:30915197), partial cds.
KJ894715 - Synthetic construct Homo sapiens clone ccsbBroadEn_04109 ZNF322 gene, encodes complete protein.
EU446529 - Synthetic construct Homo sapiens clone IMAGE:100069819; IMAGE:100011738; FLH258561.01L zinc finger protein 322A (ZNF322A) gene, encodes complete protein.
AB385592 - Synthetic construct DNA, clone: pF1KB9536, Homo sapiens ZNF322A gene for zinc finger protein 322A, complete cds, without stop codon, in Flexi system.
CU690670 - Synthetic construct Homo sapiens gateway clone IMAGE:100021401 5' read ZNF322A mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1X3, NM_001242798, NP_078915, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9, ZN322_HUMAN, ZNF322A, ZNF388, ZNF489
UCSC ID: uc021yny.1
RefSeq Accession: NM_001242798
Protein: Q6U7Q0 (aka ZN322_HUMAN)
CCDS: CCDS4617.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001242798.1
exon count: 3CDS single in 3' UTR: no RNA size: 4747
ORF size: 1209CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2446.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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