Human Gene ZNF322 (uc021yny.1) Description and Page Index
  Description: Homo sapiens zinc finger protein 322 (ZNF322), transcript variant 3, mRNA.
RefSeq Summary (NM_001242798): ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:26,634,611-26,659,980 Size: 25,370 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr6:26,637,573-26,638,781 Size: 1,209 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:26,634,611-26,659,980)mRNA (may differ from genome)Protein (402 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 322; AltName: Full=Zinc finger protein 322A; AltName: Full=Zinc finger protein 388; AltName: Full=Zinc finger protein 489;
FUNCTION: Involved in transcriptional regulation as an activator.
TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart and skeletal muscle.
DEVELOPMENTAL STAGE: Expressed in embryo as early as the 11th week of gestation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.70 RPKM in Bladder
Total median expression: 74.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -209.06576-0.363 Picture PostScript Text
3' UTR -829.682962-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q6U7Q0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0035326 enhancer binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:1902459 positive regulation of stem cell population maintenance

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  DQ786258 - Homo sapiens clone HLS_IMAGE_282884 mRNA sequence.
BC058829 - Homo sapiens HLA complex group 12, mRNA (cDNA clone IMAGE:4775484).
BC107578 - Homo sapiens cDNA clone IMAGE:4334226.
BC070371 - Homo sapiens HLA complex group 12, mRNA (cDNA clone IMAGE:4657554).
AK027046 - Homo sapiens cDNA: FLJ23393 fis, clone HEP17447.
AY376736 - Homo sapiens zinc finger protein 322 (ZNF322) mRNA, complete cds.
JD174867 - Sequence 155891 from Patent EP1572962.
JD561653 - Sequence 542677 from Patent EP1572962.
BC050425 - Homo sapiens zinc finger protein 322A, mRNA (cDNA clone MGC:54129 IMAGE:6473688), complete cds.
JD278726 - Sequence 259750 from Patent EP1572962.
JD270388 - Sequence 251412 from Patent EP1572962.
JD064186 - Sequence 45210 from Patent EP1572962.
BC119669 - Homo sapiens zinc finger protein 322A, mRNA (cDNA clone MGC:149551 IMAGE:40116184), complete cds.
BC139750 - Homo sapiens cDNA clone IMAGE:40116185, containing frame-shift errors.
JD271457 - Sequence 252481 from Patent EP1572962.
AK290038 - Homo sapiens cDNA FLJ76346 complete cds, highly similar to Homo sapiens zinc finger protein 322A (ZNF322A), mRNA.
BC074772 - Homo sapiens zinc finger protein 322A, mRNA (cDNA clone IMAGE:30915197), partial cds.
KJ894715 - Synthetic construct Homo sapiens clone ccsbBroadEn_04109 ZNF322 gene, encodes complete protein.
EU446529 - Synthetic construct Homo sapiens clone IMAGE:100069819; IMAGE:100011738; FLH258561.01L zinc finger protein 322A (ZNF322A) gene, encodes complete protein.
AB385592 - Synthetic construct DNA, clone: pF1KB9536, Homo sapiens ZNF322A gene for zinc finger protein 322A, complete cds, without stop codon, in Flexi system.
CU690670 - Synthetic construct Homo sapiens gateway clone IMAGE:100021401 5' read ZNF322A mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1X3, NM_001242798, NP_078915, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9, ZN322_HUMAN, ZNF322A, ZNF388, ZNF489
UCSC ID: uc021yny.1
RefSeq Accession: NM_001242798
Protein: Q6U7Q0 (aka ZN322_HUMAN)
CCDS: CCDS4617.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001242798.1
exon count: 3CDS single in 3' UTR: no RNA size: 4747
ORF size: 1209CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2446.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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