Human Gene ZNF773 (uc002qox.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 773 (ZNF773), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:58,011,309-58,019,510 Size: 8,202 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:58,011,449-58,018,792 Size: 7,344 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:58,011,309-58,019,510)mRNA (may differ from genome)Protein (442 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZN773_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 773; AltName: Full=Zinc finger protein 419B;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.36 RPKM in Thyroid
Total median expression: 39.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -66.20140-0.473 Picture PostScript Text
3' UTR -241.40718-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q6PK81
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK057209 - Homo sapiens cDNA FLJ32647 fis, clone SYNOV2001374, moderately similar to ZINC FINGER PROTEIN 134.
AK160372 - Homo sapiens mRNA for FLJ00301 protein.
BC005167 - Homo sapiens zinc finger protein 773, mRNA (cDNA clone MGC:4728 IMAGE:3535599), complete cds.
EU446945 - Synthetic construct Homo sapiens clone IMAGE:100070246; IMAGE:100012154; FLH258750.01L zinc finger protein 773 (ZNF773) gene, encodes complete protein.
DQ601261 - Homo sapiens piRNA piR-39327, complete sequence.
JD314815 - Sequence 295839 from Patent EP1572962.
DQ571817 - Homo sapiens piRNA piR-31929, complete sequence.
JD286500 - Sequence 267524 from Patent EP1572962.
JD496045 - Sequence 477069 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6PK81 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_198542, NP_940944, Q6PK81, Q96DL8, ZN773_HUMAN, ZNF419B
UCSC ID: uc002qox.3
RefSeq Accession: NM_198542
Protein: Q6PK81 (aka ZN773_HUMAN)
CCDS: CCDS33134.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198542.1
exon count: 4CDS single in 3' UTR: no RNA size: 2206
ORF size: 1329CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 2855.00frame shift in genome: no % Coverage: 99.14
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.