Human Gene TAS2R20 (uc001qzm.2) Description and Page Index
Description: Homo sapiens taste receptor, type 2, member 20 (TAS2R20), mRNA. RefSeq Summary (NM_176889): This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr12:11,148,561-11,150,474 Size: 1,914 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chr12:11,149,545-11,150,474 Size: 930 Coding Exon Count: 1
ID:T2R20_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 2 member 20; AltName: Full=Taste receptor type 2 member 49; Short=T2R49; AltName: Full=Taste receptor type 2 member 56; Short=T2R56; FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05296 - Taste receptor protein (TAS2R)
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P59543
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste