ID:GLD2_HUMAN DESCRIPTION: RecName: Full=Poly(A) RNA polymerase GLD2; Short=hGLD-2; EC=18.104.22.168; AltName: Full=PAP-associated domain-containing protein 4; AltName: Full=Terminal uridylyltransferase 2; Short=TUTase 2; FUNCTION: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. CATALYTIC ACTIVITY: ATP + RNA(n) = diphosphate + RNA(n+1). COFACTOR: Magnesium or manganese (By similarity). SUBUNIT: Interacts with CPEB1, CPEB2, CPSF1 and PABPC1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla. SIMILARITY: Belongs to the DNA polymerase type-B-like family. GLD2 subfamily. SIMILARITY: Contains 1 PAP-associated domain.
Genetic Association Studies of Complex Diseases and Disorders
Hemoglobin A, Glycosylated James B Meigs et al. BMC medical genetics 2007, Genome-wide association with diabetes-related traits in the Framingham Heart Study., BMC medical genetics.
Framingham 100K SNP data is a resource for association tests of known and novel genes with diabetes and related traits posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 webcite. Framingham 100K data replicate the TCF7L2 association with diabetes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PIY7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.