Human Gene SKIV2L2 (uc003jpy.4) Description and Page Index
Description: Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae) (SKIV2L2), mRNA.
Transcript (Including UTRs)
Position: hg19 chr5:54,603,576-54,721,409 Size: 117,834 Total Exon Count: 27 Strand: +
Position: hg19 chr5:54,603,842-54,720,600 Size: 116,759 Coding Exon Count: 27
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Superkiller viralicidic activity 2-like 2; EC=184.108.40.206; AltName: Full=ATP-dependent helicase SKIV2L2;
FUNCTION: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Associated with the RNA exosome complex. Identified in the spliceosome C complex. INTERACTION: Q99547:MPHOSPH6; NbExp=2; IntAct=EBI-347612, EBI-373187; SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the helicase family. SKI2 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SEQUENCE CAUTION: Sequence=AAH65258.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA06124.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
SKIV2L2 CDC HuGE Published Literature:
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR012961 - DSH_C
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR016438 - RNA_helicase_ATP-dep_SK12/DOB1
IPR025696 - rRNA_proc-arch_dom
Pfam Domains: PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain
PF08148 - DSHCT (NUC185) domain
PF13234 - rRNA-processing arch domain
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases
ModBase Predicted Comparative 3D Structure on P42285
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BX640789 - Homo sapiens mRNA; cDNA DKFZp686K2075 (from clone DKFZp686K2075). BC104996 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:132656 IMAGE:8143999), complete cds. BC113509 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:142069 IMAGE:8322561), complete cds. BC028604 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:33192 IMAGE:4820164), complete cds. AK291649 - Homo sapiens cDNA FLJ76877 complete cds, highly similar to Homo sapiens superkiller viralicidic activity 2-like 2 (SKIV2L2), mRNA. AK304788 - Homo sapiens cDNA FLJ55446 complete cds, highly similar to Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-). D29641 - Homo sapiens KIAA0052 mRNA for KIAA0052 protein. BC065258 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:6146338), partial cds. AB527662 - Synthetic construct DNA, clone: pF1KB0496, Homo sapiens SKIV2L2 gene for superkiller viralicidic activity 2-like 2, without stop codon, in Flexi system. KJ898500 - Synthetic construct Homo sapiens clone ccsbBroadEn_07894 SKIV2L2 gene, encodes complete protein. BC014669 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:4849317), partial cds. BC031779 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:4520464), partial cds. BC105291 - Homo sapiens superkiller viralicidic activity 2-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:6652652), partial cds. AF085966 - Homo sapiens full length insert cDNA clone YS84B07. AK123505 - Homo sapiens cDNA FLJ41511 fis, clone BRTHA2010008. JD105188 - Sequence 86212 from Patent EP1572962. JD347566 - Sequence 328590 from Patent EP1572962. JD042395 - Sequence 23419 from Patent EP1572962. CU691781 - Synthetic construct Homo sapiens gateway clone IMAGE:100021102 3' read PPAP2A mRNA. JD139329 - Sequence 120353 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: KIAA0052, Mtr4, NM_015360, NP_056175, P42285, Q2M386, Q6MZZ8, Q6P170, Q8N5R0, Q8TAG2, SK2L2_HUMAN UCSC ID: uc003jpy.4 RefSeq Accession: NM_015360
(aka SK2L2_HUMAN) P42285
Gene Model Information
27 CDS single in 3' UTR:
3129 CDS single in intron:
Alignment % ID:
5000.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.