Human Gene NUP54 (uc003hjs.3) Description and Page Index
Description: Homo sapiens nucleoporin 54kDa (NUP54), mRNA. RefSeq Summary (NM_017426): The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]. Transcript (Including UTRs) Position: hg19 chr4:77,035,817-77,069,655 Size: 33,839 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr4:77,036,519-77,069,527 Size: 33,009 Coding Exon Count: 12
ID:NUP54_HUMAN DESCRIPTION: RecName: Full=Nucleoporin p54; AltName: Full=54 kDa nucleoporin; FUNCTION: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity). SUBUNIT: Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUPL1 (By similarity). SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity). DOMAIN: Contains FG repeats. PTM: O-glycosylated (By similarity). SIMILARITY: Belongs to the NUP54 family. SEQUENCE CAUTION: Sequence=BAA91735.1; Type=Frameshift; Positions=479;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z3B4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.