ID:BFAR_HUMAN DESCRIPTION: RecName: Full=Bifunctional apoptosis regulator; AltName: Full=RING finger protein 47; FUNCTION: Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. SUBUNIT: Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): BFAR CDC HuGE Published Literature: BFAR
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZS9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006511 ubiquitin-dependent protein catabolic process GO:0006915 apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0051865 protein autoubiquitination GO:0070534 protein K63-linked ubiquitination GO:0070936 protein K48-linked ubiquitination GO:1903895 negative regulation of IRE1-mediated unfolded protein response