Human Gene ZC3H7A (uc002dbl.3) Description and Page Index
  Description: Homo sapiens zinc finger CCCH-type containing 7A (ZC3H7A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:11,844,442-11,891,114 Size: 46,673 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg19 chr16:11,845,173-11,876,210 Size: 31,038 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:11,844,442-11,891,114)mRNA (may differ from genome)Protein (971 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Z3H7A_HUMAN
DESCRIPTION: RecName: Full=Zinc finger CCCH domain-containing protein 7A;
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Contains 1 C2H2-type zinc finger.
SIMILARITY: Contains 3 C3H1-type zinc fingers.
SIMILARITY: Contains 3 TPR repeats.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZC3H7A
CDC HuGE Published Literature: ZC3H7A
Positive Disease Associations: Alcohol Drinking , QT interval , Triglycerides
Related Studies:
  1. Alcohol Drinking
    , , . [PubMed 0]
  2. QT interval
    Newton-Cheh ,et al. 2009, Common variants at ten loci influence QT interval duation in the QTGEN Study, Nature genetics 2009 41- 4 : 399-406. [PubMed 19305408]
  3. Triglycerides
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.27 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 549.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.80169-0.372 Picture PostScript Text
3' UTR -196.90731-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011990 - TPR-like_helical
IPR015880 - Znf_C2H2-like
IPR000571 - Znf_CCCH

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
90229 - CCCH zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D9M
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q8IWR0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
      
      
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0035198 miRNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0010608 posttranscriptional regulation of gene expression
GO:0035196 production of miRNAs involved in gene silencing by miRNA

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK026956 - Homo sapiens cDNA: FLJ23303 fis, clone HEP11157, highly similar to AF161540 Homo sapiens HSPC055 mRNA.
AY163807 - Homo sapiens zinc-finger protein mRNA, complete cds.
AK001869 - Homo sapiens cDNA FLJ11007 fis, clone PLACE1003092.
BX647154 - Homo sapiens mRNA; cDNA DKFZp686H18275 (from clone DKFZp686H18275).
AF161540 - Homo sapiens HSPC055 mRNA, complete cds.
AK026827 - Homo sapiens cDNA: FLJ23174 fis, clone LNG10049, highly similar to AF161540 Homo sapiens HSPC055 mRNA.
BC012575 - Homo sapiens zinc finger CCCH-type containing 7A, mRNA (cDNA clone IMAGE:4291095), complete cds.
BC046363 - Homo sapiens zinc finger CCCH-type containing 7A, mRNA (cDNA clone MGC:50782 IMAGE:5538820), complete cds.
AK000889 - Homo sapiens cDNA FLJ10027 fis, clone HEMBA1000727.
JD503401 - Sequence 484425 from Patent EP1572962.
JD562730 - Sequence 543754 from Patent EP1572962.
JD094238 - Sequence 75262 from Patent EP1572962.
JD559092 - Sequence 540116 from Patent EP1572962.
JD174557 - Sequence 155581 from Patent EP1572962.
JD524496 - Sequence 505520 from Patent EP1572962.
JD278567 - Sequence 259591 from Patent EP1572962.
JD029472 - Sequence 10496 from Patent EP1572962.
JD021016 - Sequence 2040 from Patent EP1572962.
JD254115 - Sequence 235139 from Patent EP1572962.
JD304191 - Sequence 285215 from Patent EP1572962.
KJ902500 - Synthetic construct Homo sapiens clone ccsbBroadEn_11894 ZC3H7A gene, encodes complete protein.
AK000325 - Homo sapiens cDNA FLJ20318 fis, clone HEP08704.
AK091803 - Homo sapiens cDNA FLJ34484 fis, clone HLUNG2004159, weakly similar to Ubiquitous tetratricopeptide containing protein RoXaN.
AX747194 - Sequence 719 from Patent EP1308459.
BC036857 - Homo sapiens zinc finger CCCH-type containing 7A, mRNA (cDNA clone IMAGE:5527491), partial cds.
JD458495 - Sequence 439519 from Patent EP1572962.
JD458496 - Sequence 439520 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DUG5, HSPC055, NM_014153, NP_054872, Q8IWR0, Q9NPE9, uc002dbk.3, Z3H7A_HUMAN, ZC3H7, ZC3HDC7
UCSC ID: uc002dbl.3
RefSeq Accession: NM_014153
Protein: Q8IWR0 (aka Z3H7A_HUMAN)
CCDS: CCDS10550.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014153.3
exon count: 23CDS single in 3' UTR: no RNA size: 3817
ORF size: 2916CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6025.00frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.