Human Gene NAT10 (uc001mvk.3) Description and Page Index
  Description: Homo sapiens N-acetyltransferase 10 (GCN5-related) (NAT10), transcript variant 1, mRNA.
RefSeq Summary (NM_024662): The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016].
Transcript (Including UTRs)
   Position: hg19 chr11:34,127,111-34,168,458 Size: 41,348 Total Exon Count: 29 Strand: +
Coding Region
   Position: hg19 chr11:34,129,773-34,167,739 Size: 37,967 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:34,127,111-34,168,458)mRNA (may differ from genome)Protein (1025 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NAT10_HUMAN
DESCRIPTION: RecName: Full=N-acetyltransferase 10; EC=2.3.1.-;
FUNCTION: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division.
SUBUNIT: Interacts with SUN1 (via N-terminus). Also interacts with TERT.
INTERACTION: Q9NX58:LYAR; NbExp=1; IntAct=EBI-876527, EBI-713507;
SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase.
INDUCTION: Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular resistance to genotoxic agents.
SIMILARITY: Belongs to the UPF0202 family.
SIMILARITY: Contains 1 N-acetyltransferase domain.
SEQUENCE CAUTION: Sequence=AAO49126.1; Type=Frameshift; Positions=981; Sequence=BAB21800.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 508.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.32244-0.341 Picture PostScript Text
3' UTR -256.80719-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016181 - Acyl_CoA_acyltransferase
IPR013562 - DUF1726
IPR000182 - GNAT_dom
IPR007807 - Helicase_dom

Pfam Domains:
PF05127 - Helicase
PF08351 - Domain of unknown function (DUF1726)
PF13718 - GNAT acetyltransferase 2
PF13725 - Possible tRNA binding domain

ModBase Predicted Comparative 3D Structure on Q9H0A0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008080 N-acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0051392 tRNA N-acetyltransferase activity
GO:0070182 DNA polymerase binding
GO:1990883 rRNA cytidine N-acetyltransferase activity

Biological Process:
GO:0000154 rRNA modification
GO:0002101 tRNA wobble cytosine modification
GO:0006364 rRNA processing
GO:0008033 tRNA processing
GO:0016072 rRNA metabolic process
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0034470 ncRNA processing
GO:0051391 tRNA acetylation
GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA

Cellular Component:
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030496 midbody
GO:0030686 90S preribosome
GO:0005697 telomerase holoenzyme complex


-  Descriptions from all associated GenBank mRNAs
  LF205798 - JP 2014500723-A/13301: Polycomb-Associated Non-Coding RNAs.
AK225341 - Homo sapiens mRNA for N-acetyltransferase-like protein variant, clone: HEP09068.
AK022241 - Homo sapiens cDNA FLJ12179 fis, clone MAMMA1000738, moderately similar to HYPOTHETICAL 116.5 KD PROTEIN C20G8.09C IN CHROMOSOME I.
BC035558 - Homo sapiens N-acetyltransferase 10 (GCN5-related), mRNA (cDNA clone MGC:40254 IMAGE:5166101), complete cds.
AB051496 - Homo sapiens KIAA1709 mRNA for KIAA1709 protein.
AK294044 - Homo sapiens cDNA FLJ58528 complete cds, highly similar to N-acetyltransferase 10 (EC 2.3.1.-).
AL136882 - Homo sapiens mRNA; cDNA DKFZp434C116 (from clone DKFZp434C116).
AK001636 - Homo sapiens cDNA FLJ10774 fis, clone NT2RP4000290.
JD396799 - Sequence 377823 from Patent EP1572962.
BC014440 - Homo sapiens N-acetyltransferase 10, mRNA (cDNA clone IMAGE:4866547), with apparent retained intron.
BC020205 - Homo sapiens N-acetyltransferase 10 (GCN5-related), mRNA (cDNA clone IMAGE:4857480), partial cds.
JD164617 - Sequence 145641 from Patent EP1572962.
AK074430 - Homo sapiens cDNA FLJ23850 fis, clone KAT11183.
JD315835 - Sequence 296859 from Patent EP1572962.
AM393096 - Synthetic construct Homo sapiens clone IMAGE:100002017 for hypothetical protein (NAT10 gene).
AB384266 - Synthetic construct DNA, clone: pF1KSDA1709, Homo sapiens NAT10 gene for N-acetyltransferase 10, complete cds, without stop codon, in Flexi system.
CU690104 - Synthetic construct Homo sapiens gateway clone IMAGE:100020503 5' read NAT10 mRNA.
KJ894160 - Synthetic construct Homo sapiens clone ccsbBroadEn_03554 NAT10 gene, encodes complete protein.
AF489535 - Homo sapiens N-acetyltransferase-like protein mRNA, complete cds.
DQ570663 - Homo sapiens piRNA piR-30775, complete sequence.
LF348362 - JP 2014500723-A/155865: Polycomb-Associated Non-Coding RNAs.
LF348359 - JP 2014500723-A/155862: Polycomb-Associated Non-Coding RNAs.
LF348355 - JP 2014500723-A/155858: Polycomb-Associated Non-Coding RNAs.
JD027806 - Sequence 8830 from Patent EP1572962.
LF348352 - JP 2014500723-A/155855: Polycomb-Associated Non-Coding RNAs.
LF348350 - JP 2014500723-A/155853: Polycomb-Associated Non-Coding RNAs.
LF348348 - JP 2014500723-A/155851: Polycomb-Associated Non-Coding RNAs.
LF348347 - JP 2014500723-A/155850: Polycomb-Associated Non-Coding RNAs.
LF348346 - JP 2014500723-A/155849: Polycomb-Associated Non-Coding RNAs.
JD350068 - Sequence 331092 from Patent EP1572962.
JD193432 - Sequence 174456 from Patent EP1572962.
JD449874 - Sequence 430898 from Patent EP1572962.
JD500009 - Sequence 481033 from Patent EP1572962.
JD193290 - Sequence 174314 from Patent EP1572962.
JD445190 - Sequence 426214 from Patent EP1572962.
JD216868 - Sequence 197892 from Patent EP1572962.
JD205533 - Sequence 186557 from Patent EP1572962.
JD262438 - Sequence 243462 from Patent EP1572962.
JD478746 - Sequence 459770 from Patent EP1572962.
JD507063 - Sequence 488087 from Patent EP1572962.
LF348345 - JP 2014500723-A/155848: Polycomb-Associated Non-Coding RNAs.
JD522866 - Sequence 503890 from Patent EP1572962.
MA583939 - JP 2018138019-A/155865: Polycomb-Associated Non-Coding RNAs.
MA583936 - JP 2018138019-A/155862: Polycomb-Associated Non-Coding RNAs.
MA583932 - JP 2018138019-A/155858: Polycomb-Associated Non-Coding RNAs.
MA583929 - JP 2018138019-A/155855: Polycomb-Associated Non-Coding RNAs.
MA583927 - JP 2018138019-A/155853: Polycomb-Associated Non-Coding RNAs.
MA583925 - JP 2018138019-A/155851: Polycomb-Associated Non-Coding RNAs.
MA583924 - JP 2018138019-A/155850: Polycomb-Associated Non-Coding RNAs.
MA583923 - JP 2018138019-A/155849: Polycomb-Associated Non-Coding RNAs.
MA583922 - JP 2018138019-A/155848: Polycomb-Associated Non-Coding RNAs.
MA441375 - JP 2018138019-A/13301: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H0A0 (Reactome details) participates in the following event(s):

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: ALP, KIAA1709, NAT10_HUMAN, NM_024662, NP_078938, Q86WK5, Q9C0F4, Q9H0A0, Q9HA61, Q9NVF2
UCSC ID: uc001mvk.3
RefSeq Accession: NM_024662
Protein: Q9H0A0 (aka NAT10_HUMAN)
CCDS: CCDS7889.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_024662.2
exon count: 29CDS single in 3' UTR: no RNA size: 4058
ORF size: 3078CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 6320.00frame shift in genome: no % Coverage: 99.58
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.