Human Gene NAT10 (uc001mvk.3) Description and Page Index
Description: Homo sapiens N-acetyltransferase 10 (GCN5-related) (NAT10), transcript variant 1, mRNA. RefSeq Summary (NM_024662): The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr11:34,127,111-34,168,458 Size: 41,348 Total Exon Count: 29 Strand: + Coding Region Position: hg19 chr11:34,129,773-34,167,739 Size: 37,967 Coding Exon Count: 28
ID:NAT10_HUMAN DESCRIPTION: RecName: Full=N-acetyltransferase 10; EC=2.3.1.-; FUNCTION: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division. SUBUNIT: Interacts with SUN1 (via N-terminus). Also interacts with TERT. INTERACTION: Q9NX58:LYAR; NbExp=1; IntAct=EBI-876527, EBI-713507; SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. INDUCTION: Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular resistance to genotoxic agents. SIMILARITY: Belongs to the UPF0202 family. SIMILARITY: Contains 1 N-acetyltransferase domain. SEQUENCE CAUTION: Sequence=AAO49126.1; Type=Frameshift; Positions=981; Sequence=BAB21800.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05127 - Helicase PF08351 - Domain of unknown function (DUF1726) PF13718 - GNAT acetyltransferase 2 PF13725 - Possible tRNA binding domain
ModBase Predicted Comparative 3D Structure on Q9H0A0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.