Human Gene FTSJD1 (uc010cga.3) Description and Page Index
  Description: Homo sapiens FtsJ methyltransferase domain containing 1 (FTSJD1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:71,316,203-71,323,315 Size: 7,113 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr16:71,317,511-71,319,823 Size: 2,313 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,316,203-71,323,315)mRNA (may differ from genome)Protein (770 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FTSJ1_HUMAN
DESCRIPTION: RecName: Full=FtsJ methyltransferase domain-containing protein 1; EC=2.1.1.-; AltName: Full=Protein adrift homolog;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the methyltransferase superfamily. RlmE family. Adrift subfamily.
SEQUENCE CAUTION: Sequence=AAM49718.1; Type=Frameshift; Positions=337; Sequence=BAA91058.1; Type=Frameshift; Positions=739; Sequence=BAB14452.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.86 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 188.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -186.90406-0.460 Picture PostScript Text
3' UTR -307.041308-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025807 - Adrift_MeTrfase
IPR002877 - rRNA_MeTrfase_FtsJ_dom

Pfam Domains:
PF01728 - FtsJ-like methyltransferase

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q8IYT2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0006370 7-methylguanosine mRNA capping
GO:0006397 mRNA processing
GO:0032259 methylation
GO:0097310 cap2 mRNA methylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BX648660 - Homo sapiens mRNA; cDNA DKFZp686P1938 (from clone DKFZp686P1938).
AK023183 - Homo sapiens cDNA FLJ13121 fis, clone NT2RP3002687.
BC035005 - Homo sapiens FtsJ methyltransferase domain containing 1, mRNA (cDNA clone MGC:33269 IMAGE:5267637), complete cds.
AK000289 - Homo sapiens cDNA FLJ20282 fis, clone HEP03828.
BC034468 - Homo sapiens FtsJ methyltransferase domain containing 1, mRNA (cDNA clone MGC:26159 IMAGE:4824516), complete cds.
JD314139 - Sequence 295163 from Patent EP1572962.
JD508258 - Sequence 489282 from Patent EP1572962.
AK002033 - Homo sapiens cDNA FLJ11171 fis, clone PLACE1007317, weakly similar to Drosophila melanogaster Adrift mRNA.
JD226325 - Sequence 207349 from Patent EP1572962.
JD155180 - Sequence 136204 from Patent EP1572962.
AK226169 - Homo sapiens mRNA for hypothetical protein LOC55783 variant, clone: ej01021.
AK315056 - Homo sapiens cDNA, FLJ96008.
JF432273 - Synthetic construct Homo sapiens clone IMAGE:100073445 FtsJ methyltransferase domain containing 1 (FLJ11171) gene, encodes complete protein.
KJ899192 - Synthetic construct Homo sapiens clone ccsbBroadEn_08586 FTSJD1 gene, encodes complete protein.
AB385037 - Synthetic construct DNA, clone: pF1KB5099, Homo sapiens FLJ11171 gene for FLJ11171 protein, complete cds, without stop codon, in Flexi system.
AF458590 - Homo sapiens hypothetical protein mRNA, complete cds.
CU690018 - Synthetic construct Homo sapiens gateway clone IMAGE:100020069 5' read FLJ11171 mRNA.
AK123343 - Homo sapiens cDNA FLJ41349 fis, clone BRAWH2012077.

-  Other Names for This Gene
  Alternate Gene Symbols: AFT, B2RCD5, D3DWS1, FTSJ1_HUMAN, NM_001099642, NP_060818, Q8IYT2, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5
UCSC ID: uc010cga.3
RefSeq Accession: NM_001099642
Protein: Q8IYT2 (aka FTSJ1_HUMAN)
CCDS: CCDS10898.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001099642.1
exon count: 3CDS single in 3' UTR: no RNA size: 4040
ORF size: 2313CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4805.00frame shift in genome: no % Coverage: 99.68
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.