Human Gene PGGT1B (uc003kqw.4) Description and Page Index
Description: Homo sapiens protein geranylgeranyltransferase type I, beta subunit (PGGT1B), mRNA. RefSeq Summary (NM_005023): Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.41166.1, SRR3476690.950674.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000419445.6/ ENSP00000404676.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr5:114,546,527-114,598,569 Size: 52,043 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr5:114,548,099-114,598,548 Size: 50,450 Coding Exon Count: 9
ID:PGTB1_HUMAN DESCRIPTION: RecName: Full=Geranylgeranyl transferase type-1 subunit beta; EC=184.108.40.206; AltName: Full=Geranylgeranyl transferase type I subunit beta; Short=GGTase-I-beta; AltName: Full=Type I protein geranyl-geranyltransferase subunit beta; FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding. CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Heterodimer of an alpha and a beta subunit. SIMILARITY: Belongs to the protein prenyltransferase subunit beta family. SIMILARITY: Contains 4 PFTB repeats.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PGGT1B CDC HuGE Published Literature: PGGT1B
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53609
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008284 positive regulation of cell proliferation GO:0018344 protein geranylgeranylation GO:0034097 response to cytokine GO:0045787 positive regulation of cell cycle GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
L25441 - Human geranylgeranyltransferase type I beta-subunit mRNA, complete cds. AY780790 - Homo sapiens geranylgeranyltransferase type I beta subunit (PGGT1B) mRNA, complete cds, alternatively spliced. AB590094 - Synthetic construct DNA, clone: pFN21AE0555, Homo sapiens PGGT1B gene for protein geranylgeranyltransferase type I, beta subunit, without stop codon, in Flexi system. BC111924 - Synthetic construct Homo sapiens clone IMAGE:40080750, MGC:133463 PGGT1B protein (PGGT1B) mRNA, encodes complete protein. BC118496 - Synthetic construct Homo sapiens clone IMAGE:40080759, MGC:155332 PGGT1B protein (PGGT1B) mRNA, encodes complete protein. JD562996 - Sequence 544020 from Patent EP1572962. JD437534 - Sequence 418558 from Patent EP1572962.