Human Gene ZNF780B (uc002omu.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 780B (ZNF780B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:40,534,167-40,562,115 Size: 27,949 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:40,540,264-40,556,239 Size: 15,976 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:40,534,167-40,562,115)mRNA (may differ from genome)Protein (833 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 780B; AltName: Full=Zinc finger protein 779;
FUNCTION: May be involved in transcriptional regulation (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 23 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.35 RPKM in Pituitary
Total median expression: 137.32 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.4065-0.206 Picture PostScript Text
3' UTR -1897.296097-0.311 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9Y6R6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF384232 - JP 2014500723-A/191735: Polycomb-Associated Non-Coding RNAs.
AK122872 - Homo sapiens cDNA FLJ16506 fis, clone FEBRA2019519, moderately similar to Zinc finger protein HZF10.
AK127063 - Homo sapiens cDNA FLJ45120 fis, clone BRAWH3035936, moderately similar to Zinc finger protein 208.
JD316290 - Sequence 297314 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
BC136960 - Homo sapiens zinc finger protein 780B, mRNA (cDNA clone MGC:168575 IMAGE:9020952), complete cds.
JD032199 - Sequence 13223 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
LF367206 - JP 2014500723-A/174709: Polycomb-Associated Non-Coding RNAs.
JD314884 - Sequence 295908 from Patent EP1572962.
JD082710 - Sequence 63734 from Patent EP1572962.
JD032199 - Sequence 13223 from Patent EP1572962.
JD327137 - Sequence 308161 from Patent EP1572962.
JD313185 - Sequence 294209 from Patent EP1572962.
LF367207 - JP 2014500723-A/174710: Polycomb-Associated Non-Coding RNAs.
JD280098 - Sequence 261122 from Patent EP1572962.
JD471529 - Sequence 452553 from Patent EP1572962.
JD497248 - Sequence 478272 from Patent EP1572962.
JD264085 - Sequence 245109 from Patent EP1572962.
JD206789 - Sequence 187813 from Patent EP1572962.
MA619809 - JP 2018138019-A/191735: Polycomb-Associated Non-Coding RNAs.
MA602783 - JP 2018138019-A/174709: Polycomb-Associated Non-Coding RNAs.
MA602784 - JP 2018138019-A/174710: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B9EH00, NM_001005851, NP_001005851, Q9Y6R6, Z780B_HUMAN, ZNF779
UCSC ID: uc002omu.3
RefSeq Accession: NM_001005851
Protein: Q9Y6R6 (aka Z780B_HUMAN)
CCDS: CCDS46077.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001005851.2
exon count: 5CDS single in 3' UTR: no RNA size: 8664
ORF size: 2502CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5198.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.