Human Gene FBXO22 (uc002bbk.3) Description and Page Index
Description: Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA. RefSeq Summary (NM_147188): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]. Transcript (Including UTRs) Position: hg19 chr15:76,196,200-76,227,608 Size: 31,409 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr15:76,196,305-76,225,443 Size: 29,139 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NEZ5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006464 cellular protein modification process GO:0006511 ubiquitin-dependent protein catabolic process GO:0006913 nucleocytoplasmic transport GO:0009267 cellular response to starvation GO:0010830 regulation of myotube differentiation GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification GO:0048742 regulation of skeletal muscle fiber development GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process