ID:CF001_HUMAN DESCRIPTION: RecName: Full=Uncharacterized protein C6orf1; AltName: Full=Protein LBH; Flags: Precursor; SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): C6orf1 CDC HuGE Published Literature: C6orf1 Positive Disease Associations: Body Height
, height Related Studies:
Body Height Amidou N'Diaye et al. PLoS genetics 2011, Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry., PLoS genetics.
height Kim ,et al. 2009, Identification of 15 loci influencing height in a Korean population, Journal of human genetics 2010 55- 1 : 27-31.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q86T20
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
AK290164 - Homo sapiens cDNA FLJ76010 complete cds. BC047919 - Homo sapiens chromosome 6 open reading frame 1, mRNA (cDNA clone MGC:57858 IMAGE:6190218), complete cds. BC023627 - Homo sapiens chromosome 6 open reading frame 1, mRNA (cDNA clone MGC:23478 IMAGE:4764944), complete cds. BC009526 - Homo sapiens chromosome 6 open reading frame 1, mRNA (cDNA clone IMAGE:3890372), with apparent retained intron. JD235146 - Sequence 216170 from Patent EP1572962. DL491604 - Novel nucleic acids. DL490199 - Novel nucleic acids. JD391892 - Sequence 372916 from Patent EP1572962. JD404011 - Sequence 385035 from Patent EP1572962. JD100157 - Sequence 81181 from Patent EP1572962. KJ900479 - Synthetic construct Homo sapiens clone ccsbBroadEn_09873 C6orf1 gene, encodes complete protein.