Human Gene TRIM41 (uc003mne.2) Description and Page Index
Description: Homo sapiens tripartite motif containing 41 (TRIM41), transcript variant 1, mRNA. RefSeq Summary (NM_033549): This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chr5:180,650,263-180,662,808 Size: 12,546 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr5:180,651,000-180,661,775 Size: 10,776 Coding Exon Count: 6
ID:TRI41_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase TRIM41; EC=6.3.2.-; AltName: Full=RING finger-interacting protein with C kinase; Short=RINCK; AltName: Full=Tripartite motif-containing protein 41; FUNCTION: Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with PRKCA. INTERACTION: P68403-2:Prkcb (xeno); NbExp=3; IntAct=EBI-726015, EBI-397092; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in multiple tissues with the highest levels in heart and skeletal muscle. PTM: Auto-ubiquitinated. SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WV44
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.