Human Gene TRIM41 (uc003mne.2) Description and Page Index
  Description: Homo sapiens tripartite motif containing 41 (TRIM41), transcript variant 1, mRNA.
RefSeq Summary (NM_033549): This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Transcript (Including UTRs)
   Position: hg19 chr5:180,650,263-180,662,808 Size: 12,546 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr5:180,651,000-180,661,775 Size: 10,776 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:180,650,263-180,662,808)mRNA (may differ from genome)Protein (630 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: TRI41_HUMAN
DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase TRIM41; EC=6.3.2.-; AltName: Full=RING finger-interacting protein with C kinase; Short=RINCK; AltName: Full=Tripartite motif-containing protein 41;
FUNCTION: Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Interacts with PRKCA.
INTERACTION: P68403-2:Prkcb (xeno); NbExp=3; IntAct=EBI-726015, EBI-397092;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed in multiple tissues with the highest levels in heart and skeletal muscle.
PTM: Auto-ubiquitinated.
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.41 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 777.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -371.40737-0.504 Picture PostScript Text
3' UTR -382.251033-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR018957 - Znf_C3HC4_RING-type
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF01442 - Apolipoprotein A1/A4/E domain
PF13445 - RING-type zinc-finger
PF13765 - SPRY-associated domain
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF15227 - zinc finger of C3HC4-type, RING

SCOP Domains:
57845 - B-box zinc-binding domain
57850 - RING/U-box

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2EGM
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q8WV44
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0016567 protein ubiquitination

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  AK027601 - Homo sapiens cDNA FLJ14695 fis, clone NT2RP2005701, highly similar to Tripartite motif-containing protein 41.
AX775793 - Sequence 63 from Patent WO03048202.
AX775801 - Sequence 71 from Patent WO03048202.
AX775799 - Sequence 69 from Patent WO03048202.
DQ601542 - Homo sapiens piRNA piR-39608, complete sequence.
BC111568 - Homo sapiens tripartite motif-containing 41, mRNA (cDNA clone IMAGE:40026654).
BC127195 - Homo sapiens tripartite motif-containing 41, mRNA (cDNA clone IMAGE:40075887), complete cds.
BC090953 - Homo sapiens tripartite motif-containing 41, mRNA (cDNA clone MGC:105071 IMAGE:6017628), complete cds.
AB100366 - Homo sapiens TRIM41a mRNA, complete cds.
AB100367 - Homo sapiens TRIM41b mRNA, complete cds.
BC004956 - Homo sapiens, clone IMAGE:3625550, mRNA, partial cds.
BC071887 - Homo sapiens tripartite motif-containing 41, mRNA (cDNA clone IMAGE:3659307), partial cds.
AK074052 - Homo sapiens mRNA for FLJ00123 protein.
AX775795 - Sequence 65 from Patent WO03048202.
AX775803 - Sequence 73 from Patent WO03048202.
AX775797 - Sequence 67 from Patent WO03048202.
BC018765 - Homo sapiens tripartite motif-containing 41, mRNA (cDNA clone IMAGE:3606188), partial cds.
AB063180 - Homo sapiens mRNA for hypothetical protein, partial cds, similar to ret finger protein.
DQ892520 - Synthetic construct clone IMAGE:100005150; FLH187113.01X; RZPDo839D1172D tripartite motif-containing 41 (TRIM41) gene, encodes complete protein.
CU676322 - Synthetic construct Homo sapiens gateway clone IMAGE:100019833 5' read TRIM41 mRNA.
KJ903555 - Synthetic construct Homo sapiens clone ccsbBroadEn_12949 TRIM41 gene, encodes complete protein.
AL832960 - Homo sapiens mRNA; cDNA DKFZp666N1710 (from clone DKFZp666N1710).
AX775789 - Sequence 59 from Patent WO03048202.
AX775791 - Sequence 61 from Patent WO03048202.
DQ572346 - Homo sapiens piRNA piR-40458, complete sequence.
AK307695 - Homo sapiens cDNA, FLJ97643.
AL137593 - Homo sapiens mRNA; cDNA DKFZp434N1710 (from clone DKFZp434N1710).
AF258579 - Homo sapiens PP4522 mRNA, complete cds.
BC009762 - Homo sapiens tripartite motif-containing 41, mRNA (cDNA clone IMAGE:2824119), partial cds.
CR457349 - Homo sapiens full open reading frame cDNA clone RZPDo834A0610D for gene TRIM41, tripartite motif-containing 41; complete cds, incl. stopcodon.
KJ903556 - Synthetic construct Homo sapiens clone ccsbBroadEn_12950 TRIM41 gene, encodes complete protein.
JD124660 - Sequence 105684 from Patent EP1572962.
JD419377 - Sequence 400401 from Patent EP1572962.
JD291688 - Sequence 272712 from Patent EP1572962.
JD430744 - Sequence 411768 from Patent EP1572962.
JD075730 - Sequence 56754 from Patent EP1572962.
JD241607 - Sequence 222631 from Patent EP1572962.
JD398939 - Sequence 379963 from Patent EP1572962.
JD061691 - Sequence 42715 from Patent EP1572962.
JD040098 - Sequence 21122 from Patent EP1572962.
JD224074 - Sequence 205098 from Patent EP1572962.
JD286503 - Sequence 267527 from Patent EP1572962.
JD482523 - Sequence 463547 from Patent EP1572962.
JD184465 - Sequence 165489 from Patent EP1572962.
JD539337 - Sequence 520361 from Patent EP1572962.
JD456358 - Sequence 437382 from Patent EP1572962.
JD359035 - Sequence 340059 from Patent EP1572962.
JD556032 - Sequence 537056 from Patent EP1572962.
JD252063 - Sequence 233087 from Patent EP1572962.
JD369438 - Sequence 350462 from Patent EP1572962.
JD332567 - Sequence 313591 from Patent EP1572962.
JD448751 - Sequence 429775 from Patent EP1572962.
JD276643 - Sequence 257667 from Patent EP1572962.
JD544811 - Sequence 525835 from Patent EP1572962.
JD245526 - Sequence 226550 from Patent EP1572962.
JD187770 - Sequence 168794 from Patent EP1572962.
JD073213 - Sequence 54237 from Patent EP1572962.
JD449865 - Sequence 430889 from Patent EP1572962.
JD214179 - Sequence 195203 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WV44 (Reactome details) participates in the following event(s):

R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B3KNJ6, D3DWR9, NM_033549, NP_291027, Q5BKT0, Q7L484, Q8WV44, Q96Q10, Q9BSL8, RINCK, TRI41_HUMAN
UCSC ID: uc003mne.2
RefSeq Accession: NM_033549
Protein: Q8WV44 (aka TRI41_HUMAN or TM41_HUMAN)
CCDS: CCDS4466.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033549.4
exon count: 6CDS single in 3' UTR: no RNA size: 3684
ORF size: 1893CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3490.50frame shift in genome: no % Coverage: 99.43
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.