Human Gene SS18L2 (uc003clk.1) Description and Page Index
Description: Homo sapiens synovial sarcoma translocation gene on chromosome 18-like 2 (SS18L2), mRNA. RefSeq Summary (NM_016305): Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]. ##Evidence-Data-START## Transcript exon combination :: BX114027.1, EL954786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: hg19 chr3:42,632,298-42,636,490 Size: 4,193 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr3:42,632,390-42,636,001 Size: 3,612 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05030 - SSXT protein (N-terminal region)
ModBase Predicted Comparative 3D Structure on Q9UHA2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.