ID:ATP9A_HUMAN DESCRIPTION: RecName: Full=Probable phospholipid-transporting ATPase IIA; EC=188.8.131.52; AltName: Full=ATPase class II type 9A; CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SUBCELLULAR LOCATION: Early endosome membrane; Multi-pass membrane protein. Recycling endosome. Golgi apparatus, trans-Golgi network membrane. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. SEQUENCE CAUTION: Sequence=BAD18775.1; Type=Erroneous initiation; Sequence=CAI18889.1; Type=Erroneous gene model prediction; Sequence=CAI19203.1; Type=Erroneous gene model prediction; Sequence=CAI22924.1; Type=Erroneous gene model prediction;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ATP9A CDC HuGE Published Literature: ATP9A
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47266 - 4-helical cytokines 81653 - Calcium ATPase, transduction domain A 56784 - HAD-like 81660 - Metal cation-transporting ATPase, ATP-binding domain N
ModBase Predicted Comparative 3D Structure on O75110
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane R-HSA-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane R-HSA-936837 Ion transport by P-type ATPases R-HSA-983712 Ion channel transport R-HSA-382551 Transport of small molecules