Human Gene ZNF428 (uc002oxa.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 428 (ZNF428), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:44,111,376-44,124,014 Size: 12,639 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:44,111,769-44,118,456 Size: 6,688 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:44,111,376-44,124,014)mRNA (may differ from genome)Protein (188 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 428; AltName: Full=Enzyme-like protein PIT13;
SIMILARITY: Contains 1 C2H2-type zinc finger.
SEQUENCE CAUTION: Sequence=AAC99795.1; Type=Erroneous gene model prediction; Sequence=AAP87382.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.35 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 963.21 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -192.60435-0.443 Picture PostScript Text
3' UTR -120.36393-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

ModBase Predicted Comparative 3D Structure on Q96B54
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

-  Descriptions from all associated GenBank mRNAs
  BC045799 - Homo sapiens zinc finger protein 428, mRNA (cDNA clone MGC:51082 IMAGE:4813427), complete cds.
JD479104 - Sequence 460128 from Patent EP1572962.
JD241197 - Sequence 222221 from Patent EP1572962.
BC015950 - Homo sapiens zinc finger protein 428, mRNA (cDNA clone MGC:9608 IMAGE:3908182), complete cds.
AY257197 - Homo sapiens enzyme-like protein PIT13 mRNA, complete cds.
JD090660 - Sequence 71684 from Patent EP1572962.
LF367050 - JP 2014500723-A/174553: Polycomb-Associated Non-Coding RNAs.
LF207551 - JP 2014500723-A/15054: Polycomb-Associated Non-Coding RNAs.
KJ900104 - Synthetic construct Homo sapiens clone ccsbBroadEn_09498 ZNF428 gene, encodes complete protein.
EU831792 - Synthetic construct Homo sapiens clone HAIB:100066821; DKFZo008D1221 zinc finger protein 428 protein (ZNF428) gene, encodes complete protein.
CU692294 - Synthetic construct Homo sapiens gateway clone IMAGE:100020854 5' read ZNF428 mRNA.
JD271480 - Sequence 252504 from Patent EP1572962.
JD173492 - Sequence 154516 from Patent EP1572962.
JD215259 - Sequence 196283 from Patent EP1572962.
JD467321 - Sequence 448345 from Patent EP1572962.
JD458257 - Sequence 439281 from Patent EP1572962.
JD405758 - Sequence 386782 from Patent EP1572962.
JD053700 - Sequence 34724 from Patent EP1572962.
JD160302 - Sequence 141326 from Patent EP1572962.
MA602627 - JP 2018138019-A/174553: Polycomb-Associated Non-Coding RNAs.
MA443128 - JP 2018138019-A/15054: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: C19orf37, NM_182498, NP_872304, O95054, Q6X3Y3, Q96B54, ZN428_HUMAN
UCSC ID: uc002oxa.3
RefSeq Accession: NM_182498
Protein: Q96B54 (aka ZN428_HUMAN)
CCDS: CCDS12626.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_182498.3
exon count: 3CDS single in 3' UTR: no RNA size: 1411
ORF size: 567CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1334.00frame shift in genome: no % Coverage: 98.87
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.