Human Gene MED29 (uc002olf.3) Description and Page Index
  Description: Homo sapiens mediator complex subunit 29 (MED29), mRNA.
RefSeq Summary (NM_017592): MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009].
Transcript (Including UTRs)
   Position: hg19 chr19:39,881,963-39,891,203 Size: 9,241 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:39,882,000-39,888,339 Size: 6,340 Coding Exon Count: 4 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:39,881,963-39,891,203)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.70 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 895.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.5037-0.122 Picture PostScript Text
3' UTR -1111.362864-0.388 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021018 - Mediator_Med29_met

Pfam Domains:
PF11568 - Mediator complex subunit 29

ModBase Predicted Comparative 3D Structure on B4DUA7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005654 nucleoplasm
GO:0016592 mediator complex


-  Descriptions from all associated GenBank mRNAs
  AK300563 - Homo sapiens cDNA FLJ54860 complete cds, highly similar to Homo sapiens intersex-lik (IXL), mRNA.
AY729650 - Homo sapiens intersex-like protein mRNA, complete cds.
AB528726 - Synthetic construct DNA, clone: pF1KB6991, Homo sapiens MED29 gene for mediator complex subunit 29, without stop codon, in Flexi system.
AL137304 - Homo sapiens mRNA; cDNA DKFZp434H247 (from clone DKFZp434H247).
AK298014 - Homo sapiens cDNA FLJ52870 complete cds, highly similar to Homo sapiens intersex-lik (IXL), mRNA.
AK000411 - Homo sapiens cDNA FLJ20404 fis, clone KAT01563.
BC019015 - Homo sapiens mediator complex subunit 29, mRNA (cDNA clone MGC:20644 IMAGE:4129619), complete cds.
AK092909 - Homo sapiens cDNA FLJ35590 fis, clone SPLEN2007619.
AX747802 - Sequence 1327 from Patent EP1308459.
AK316010 - Homo sapiens cDNA, FLJ78909 complete cds, highly similar to Homo sapiens intersex-lik (IXL), mRNA.
AK124629 - Homo sapiens cDNA FLJ42638 fis, clone BRACE3024659.
AK297772 - Homo sapiens cDNA FLJ52971 complete cds, highly similar to Homo sapiens intersex-lik (IXL), mRNA.
AK090877 - Homo sapiens cDNA FLJ33558 fis, clone BRAMY2009508.
AX746660 - Sequence 185 from Patent EP1308459.
AK294667 - Homo sapiens cDNA FLJ61114 complete cds, highly similar to Homo sapiens intersex-lik (IXL), mRNA.
KJ902833 - Synthetic construct Homo sapiens clone ccsbBroadEn_12227 MED29 gene, encodes complete protein.
LF325340 - JP 2014500723-A/132843: Polycomb-Associated Non-Coding RNAs.
LF325339 - JP 2014500723-A/132842: Polycomb-Associated Non-Coding RNAs.
LF325338 - JP 2014500723-A/132841: Polycomb-Associated Non-Coding RNAs.
JD272802 - Sequence 253826 from Patent EP1572962.
JD527861 - Sequence 508885 from Patent EP1572962.
JD483774 - Sequence 464798 from Patent EP1572962.
JD181177 - Sequence 162201 from Patent EP1572962.
JD303371 - Sequence 284395 from Patent EP1572962.
JD068370 - Sequence 49394 from Patent EP1572962.
JD176801 - Sequence 157825 from Patent EP1572962.
JD068769 - Sequence 49793 from Patent EP1572962.
JD399970 - Sequence 380994 from Patent EP1572962.
JD402855 - Sequence 383879 from Patent EP1572962.
JD550164 - Sequence 531188 from Patent EP1572962.
JD443321 - Sequence 424345 from Patent EP1572962.
JD192849 - Sequence 173873 from Patent EP1572962.
JD393269 - Sequence 374293 from Patent EP1572962.
JD467066 - Sequence 448090 from Patent EP1572962.
JD518250 - Sequence 499274 from Patent EP1572962.
JD428107 - Sequence 409131 from Patent EP1572962.
JD285059 - Sequence 266083 from Patent EP1572962.
JD314439 - Sequence 295463 from Patent EP1572962.
JD131217 - Sequence 112241 from Patent EP1572962.
JD535912 - Sequence 516936 from Patent EP1572962.
JD205052 - Sequence 186076 from Patent EP1572962.
JD496730 - Sequence 477754 from Patent EP1572962.
JD541009 - Sequence 522033 from Patent EP1572962.
JD493725 - Sequence 474749 from Patent EP1572962.
JD204553 - Sequence 185577 from Patent EP1572962.
JD459155 - Sequence 440179 from Patent EP1572962.
JD218804 - Sequence 199828 from Patent EP1572962.
AK026527 - Homo sapiens cDNA: FLJ22874 fis, clone KAT02871.
JD227274 - Sequence 208298 from Patent EP1572962.
JD435948 - Sequence 416972 from Patent EP1572962.
JD074612 - Sequence 55636 from Patent EP1572962.
JD474172 - Sequence 455196 from Patent EP1572962.
JD325043 - Sequence 306067 from Patent EP1572962.
JD424430 - Sequence 405454 from Patent EP1572962.
JD073827 - Sequence 54851 from Patent EP1572962.
JD038555 - Sequence 19579 from Patent EP1572962.
JD412504 - Sequence 393528 from Patent EP1572962.
JD089660 - Sequence 70684 from Patent EP1572962.
JD289119 - Sequence 270143 from Patent EP1572962.
JD079696 - Sequence 60720 from Patent EP1572962.
JD233358 - Sequence 214382 from Patent EP1572962.
JD168485 - Sequence 149509 from Patent EP1572962.
JD462123 - Sequence 443147 from Patent EP1572962.
JD162991 - Sequence 144015 from Patent EP1572962.
JD460587 - Sequence 441611 from Patent EP1572962.
JD101840 - Sequence 82864 from Patent EP1572962.
JD105540 - Sequence 86564 from Patent EP1572962.
JD158706 - Sequence 139730 from Patent EP1572962.
JD208558 - Sequence 189582 from Patent EP1572962.
JD488591 - Sequence 469615 from Patent EP1572962.
JD472424 - Sequence 453448 from Patent EP1572962.
JD440804 - Sequence 421828 from Patent EP1572962.
JD446987 - Sequence 428011 from Patent EP1572962.
JD096330 - Sequence 77354 from Patent EP1572962.
JD308768 - Sequence 289792 from Patent EP1572962.
JD331806 - Sequence 312830 from Patent EP1572962.
JD182551 - Sequence 163575 from Patent EP1572962.
JD351046 - Sequence 332070 from Patent EP1572962.
JD512884 - Sequence 493908 from Patent EP1572962.
JD097802 - Sequence 78826 from Patent EP1572962.
JD051490 - Sequence 32514 from Patent EP1572962.
JD101386 - Sequence 82410 from Patent EP1572962.
JD292579 - Sequence 273603 from Patent EP1572962.
JD155896 - Sequence 136920 from Patent EP1572962.
JD366542 - Sequence 347566 from Patent EP1572962.
JD517713 - Sequence 498737 from Patent EP1572962.
JD517714 - Sequence 498738 from Patent EP1572962.
JD105954 - Sequence 86978 from Patent EP1572962.
JD105955 - Sequence 86979 from Patent EP1572962.
JD227412 - Sequence 208436 from Patent EP1572962.
JD183032 - Sequence 164056 from Patent EP1572962.
JD397452 - Sequence 378476 from Patent EP1572962.
JD411438 - Sequence 392462 from Patent EP1572962.
JD211128 - Sequence 192152 from Patent EP1572962.
JD534713 - Sequence 515737 from Patent EP1572962.
JD089358 - Sequence 70382 from Patent EP1572962.
JD433714 - Sequence 414738 from Patent EP1572962.
DQ570859 - Homo sapiens piRNA piR-30971, complete sequence.
JD550582 - Sequence 531606 from Patent EP1572962.
JD276103 - Sequence 257127 from Patent EP1572962.
JD210052 - Sequence 191076 from Patent EP1572962.
JD457292 - Sequence 438316 from Patent EP1572962.
JD388671 - Sequence 369695 from Patent EP1572962.
JD118992 - Sequence 100016 from Patent EP1572962.
JD102130 - Sequence 83154 from Patent EP1572962.
JD229604 - Sequence 210628 from Patent EP1572962.
JD430908 - Sequence 411932 from Patent EP1572962.
JD558725 - Sequence 539749 from Patent EP1572962.
JD286825 - Sequence 267849 from Patent EP1572962.
JD344567 - Sequence 325591 from Patent EP1572962.
JD472309 - Sequence 453333 from Patent EP1572962.
JD341753 - Sequence 322777 from Patent EP1572962.
JD066296 - Sequence 47320 from Patent EP1572962.
JD537627 - Sequence 518651 from Patent EP1572962.
JD291518 - Sequence 272542 from Patent EP1572962.
JD444760 - Sequence 425784 from Patent EP1572962.
JD201393 - Sequence 182417 from Patent EP1572962.
JD430855 - Sequence 411879 from Patent EP1572962.
JD350770 - Sequence 331794 from Patent EP1572962.
JD437140 - Sequence 418164 from Patent EP1572962.
JD437139 - Sequence 418163 from Patent EP1572962.
JD281628 - Sequence 262652 from Patent EP1572962.
JD351564 - Sequence 332588 from Patent EP1572962.
JD522742 - Sequence 503766 from Patent EP1572962.
JD139798 - Sequence 120822 from Patent EP1572962.
JD364608 - Sequence 345632 from Patent EP1572962.
JD446846 - Sequence 427870 from Patent EP1572962.
MA560917 - JP 2018138019-A/132843: Polycomb-Associated Non-Coding RNAs.
MA560916 - JP 2018138019-A/132842: Polycomb-Associated Non-Coding RNAs.
MA560915 - JP 2018138019-A/132841: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DUA7, B4DUA7_HUMAN, hCG_43365, IXL, NM_017592, NP_060062
UCSC ID: uc002olf.3
RefSeq Accession: NM_017592
Protein: B4DUA7 CCDS: CCDS33021.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_017592.1
exon count: 4CDS single in 3' UTR: no RNA size: 3604
ORF size: 666CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 1532.00frame shift in genome: no % Coverage: 98.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.