Human Gene HDHD2 (uc002lcs.3) Description and Page Index
  Description: Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr18:44,633,781-44,676,871 Size: 43,091 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr18:44,635,053-44,662,810 Size: 27,758 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr18:44,633,781-44,676,871)mRNA (may differ from genome)Protein (259 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
SIMILARITY: Belongs to the HAD-like hydrolase superfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.51 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 779.47 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.00133-0.444 Picture PostScript Text
3' UTR -335.561272-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023214 - HAD-like_dom
IPR006357 - HAD-SF_hydro_IIA
IPR006355 - HAD-SF_hydro_IIA_hyp2
IPR023215 - NPhePase-like_dom

Pfam Domains:
PF13242 - HAD-hyrolase-like
PF13344 - Haloacid dehalogenase-like hydrolase
PF13419 - Haloacid dehalogenase-like hydrolase

SCOP Domains:
56784 - HAD-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9H0R4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019899 enzyme binding
GO:0046872 metal ion binding

Biological Process:
GO:0008150 biological_process
GO:0016311 dephosphorylation

Cellular Component:
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  AK054590 - Homo sapiens cDNA FLJ30028 fis, clone 3NB692001288.
AL136681 - Homo sapiens mRNA; cDNA DKFZp564D1378 (from clone DKFZp564D1378).
FJ224322 - Homo sapiens epididymis secretory protein Li 301 (HEL-S-301) mRNA, complete cds.
BC033031 - Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2, mRNA (cDNA clone MGC:33189 IMAGE:4793566), complete cds.
AK226027 - Homo sapiens mRNA for haloacid dehalogenase-like hydrolase domain containing 2 variant, clone: FCC104G07.
BC038100 - Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2, mRNA (cDNA clone MGC:32937 IMAGE:5266439), complete cds.
GQ900991 - Homo sapiens clone HEL-T-103 epididymis secretory sperm binding protein mRNA, complete cds.
JD273756 - Sequence 254780 from Patent EP1572962.
JD549644 - Sequence 530668 from Patent EP1572962.
BX537623 - Homo sapiens mRNA; cDNA DKFZp686O02188 (from clone DKFZp686O02188).
JD280638 - Sequence 261662 from Patent EP1572962.
JD168841 - Sequence 149865 from Patent EP1572962.
JD285078 - Sequence 266102 from Patent EP1572962.
JD037278 - Sequence 18302 from Patent EP1572962.
JD495694 - Sequence 476718 from Patent EP1572962.
JD067811 - Sequence 48835 from Patent EP1572962.
JD551850 - Sequence 532874 from Patent EP1572962.
JD113149 - Sequence 94173 from Patent EP1572962.
BC011894 - Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2, mRNA (cDNA clone MGC:20277 IMAGE:3944181), complete cds.
JD197055 - Sequence 178079 from Patent EP1572962.
AK292098 - Homo sapiens cDNA FLJ77359 complete cds, highly similar to Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2), mRNA.
CR533487 - Homo sapiens full open reading frame cDNA clone RZPDo834D1017D for gene DKFZP564D1378, hypothetical protein DKFZp564D1378; complete cds, incl. stopcodon.
JD048503 - Sequence 29527 from Patent EP1572962.
KJ903377 - Synthetic construct Homo sapiens clone ccsbBroadEn_12771 HDHD2 gene, encodes complete protein.
CU691536 - Synthetic construct Homo sapiens gateway clone IMAGE:100016912 5' read HDHD2 mRNA.
KJ894928 - Synthetic construct Homo sapiens clone ccsbBroadEn_04322 HDHD2 gene, encodes complete protein.
CU680098 - Synthetic construct Homo sapiens gateway clone IMAGE:100022356 5' read HDHD2 mRNA.
AB528146 - Synthetic construct DNA, clone: pF1KE0110, Homo sapiens HDHD2 gene for haloacid dehalogenase-like hydrolase domain containing protein 2, without stop codon, in Flexi system.
AM393480 - Synthetic construct Homo sapiens clone IMAGE:100001711 for hypothetical protein (HDHD2 gene).
JD395209 - Sequence 376233 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7T3, HDHD2_HUMAN, NM_032124, NP_115500, Q96NV4, Q9H0R4
UCSC ID: uc002lcs.3
RefSeq Accession: NM_032124
Protein: Q9H0R4 (aka HDHD2_HUMAN)
CCDS: CCDS32829.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032124.4
exon count: 7CDS single in 3' UTR: no RNA size: 2245
ORF size: 780CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 1681.00frame shift in genome: no % Coverage: 97.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.