Human Gene HDHD2 (uc002lcs.3) Description and Page Index
Description: Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2), mRNA.
Transcript (Including UTRs)
Position: hg19 chr18:44,633,781-44,676,871 Size: 43,091 Total Exon Count: 7 Strand: -
Position: hg19 chr18:44,635,053-44,662,810 Size: 27,758 Coding Exon Count: 6
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2;
COFACTOR: Binds 1 magnesium ion per subunit (By similarity). SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023214 - HAD-like_dom
IPR006357 - HAD-SF_hydro_IIA
IPR006355 - HAD-SF_hydro_IIA_hyp2
IPR023215 - NPhePase-like_dom
Pfam Domains: PF13242 - HAD-hyrolase-like
PF13344 - Haloacid dehalogenase-like hydrolase
PF13419 - Haloacid dehalogenase-like hydrolase
SCOP Domains: 56784 - HAD-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9H0R4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK054590 - Homo sapiens cDNA FLJ30028 fis, clone 3NB692001288. AL136681 - Homo sapiens mRNA; cDNA DKFZp564D1378 (from clone DKFZp564D1378). FJ224322 - Homo sapiens epididymis secretory protein Li 301 (HEL-S-301) mRNA, complete cds. BC033031 - Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2, mRNA (cDNA clone MGC:33189 IMAGE:4793566), complete cds. AK226027 - Homo sapiens mRNA for haloacid dehalogenase-like hydrolase domain containing 2 variant, clone: FCC104G07. BC038100 - Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2, mRNA (cDNA clone MGC:32937 IMAGE:5266439), complete cds. GQ900991 - Homo sapiens clone HEL-T-103 epididymis secretory sperm binding protein mRNA, complete cds. JD273756 - Sequence 254780 from Patent EP1572962. JD549644 - Sequence 530668 from Patent EP1572962. BX537623 - Homo sapiens mRNA; cDNA DKFZp686O02188 (from clone DKFZp686O02188). JD280638 - Sequence 261662 from Patent EP1572962. JD168841 - Sequence 149865 from Patent EP1572962. JD285078 - Sequence 266102 from Patent EP1572962. JD037278 - Sequence 18302 from Patent EP1572962. JD495694 - Sequence 476718 from Patent EP1572962. JD067811 - Sequence 48835 from Patent EP1572962. JD551850 - Sequence 532874 from Patent EP1572962. JD113149 - Sequence 94173 from Patent EP1572962. BC011894 - Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2, mRNA (cDNA clone MGC:20277 IMAGE:3944181), complete cds. JD197055 - Sequence 178079 from Patent EP1572962. AK292098 - Homo sapiens cDNA FLJ77359 complete cds, highly similar to Homo sapiens haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2), mRNA. CR533487 - Homo sapiens full open reading frame cDNA clone RZPDo834D1017D for gene DKFZP564D1378, hypothetical protein DKFZp564D1378; complete cds, incl. stopcodon. JD048503 - Sequence 29527 from Patent EP1572962. KJ903377 - Synthetic construct Homo sapiens clone ccsbBroadEn_12771 HDHD2 gene, encodes complete protein. CU691536 - Synthetic construct Homo sapiens gateway clone IMAGE:100016912 5' read HDHD2 mRNA. KJ894928 - Synthetic construct Homo sapiens clone ccsbBroadEn_04322 HDHD2 gene, encodes complete protein. CU680098 - Synthetic construct Homo sapiens gateway clone IMAGE:100022356 5' read HDHD2 mRNA. AB528146 - Synthetic construct DNA, clone: pF1KE0110, Homo sapiens HDHD2 gene for haloacid dehalogenase-like hydrolase domain containing protein 2, without stop codon, in Flexi system. AM393480 - Synthetic construct Homo sapiens clone IMAGE:100001711 for hypothetical protein (HDHD2 gene). JD395209 - Sequence 376233 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8K7T3, HDHD2_HUMAN, NM_032124, NP_115500, Q96NV4, Q9H0R4 UCSC ID: uc002lcs.3 RefSeq Accession: NM_032124
(aka HDHD2_HUMAN) Q9H0R4
Gene Model Information
7 CDS single in 3' UTR:
780 CDS single in intron:
Alignment % ID:
1681.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
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Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.