Human Gene FAM168A (uc001oty.1) Description and Page Index
  Description: Homo sapiens family with sequence similarity 168, member A (FAM168A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:73,117,028-73,309,228 Size: 192,201 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr11:73,118,576-73,179,519 Size: 60,944 Coding Exon Count: 6 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:73,117,028-73,309,228)mRNA (may differ from genome)Protein (235 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedStanford SOURCETreefamUniProtKB

-  MalaCards Disease Associations
  MalaCards Gene Search: FAM168A
Diseases sorted by gene-association score: tongue cancer (9), oral squamous cell carcinoma (6), deafness, autosomal recessive 63 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.70 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 740.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.30279-0.385 Picture PostScript Text
3' UTR -286.20780-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14944 - Tongue Cancer Chemotherapy Resistant Protein 1

ModBase Predicted Comparative 3D Structure on Q92567-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Descriptions from all associated GenBank mRNAs
  D87470 - Homo sapiens mRNA for KIAA0280 gene.
EF197985 - Homo sapiens tongue cancer chemotherapy resistance-associated protein 1 variant 1 (TCRP1) mRNA, complete cds, alternatively spliced.
BC052341 - Homo sapiens family with sequence similarity 168, member A, mRNA (cDNA clone MGC:50842 IMAGE:5757011), complete cds.
EF363480 - Homo sapiens tongue cancer chemotherapy resistance-associated protein 1 variant 2 (TCRP1) mRNA, complete cds, alternatively spliced.
AK292054 - Homo sapiens cDNA FLJ75049 complete cds.
AB383835 - Synthetic construct DNA, clone: pF1KSDA0280, Homo sapiens KIAA0280 gene for KIAA0280 protein, complete cds, without stop codon, in Flexi system.
HQ448566 - Synthetic construct Homo sapiens clone IMAGE:100072004; CCSB011367_02 KIAA0280 (KIAA0280) gene, encodes complete protein.
KJ893342 - Synthetic construct Homo sapiens clone ccsbBroadEn_02736 FAM168A gene, encodes complete protein.
CU690908 - Synthetic construct Homo sapiens gateway clone IMAGE:100021335 5' read KIAA0280 mRNA.
JD375686 - Sequence 356710 from Patent EP1572962.
JD353650 - Sequence 334674 from Patent EP1572962.
JD214621 - Sequence 195645 from Patent EP1572962.
JD278648 - Sequence 259672 from Patent EP1572962.
JD485391 - Sequence 466415 from Patent EP1572962.
JD123876 - Sequence 104900 from Patent EP1572962.
JD050143 - Sequence 31167 from Patent EP1572962.
JD090107 - Sequence 71131 from Patent EP1572962.
JD279538 - Sequence 260562 from Patent EP1572962.
JD536243 - Sequence 517267 from Patent EP1572962.
JD555536 - Sequence 536560 from Patent EP1572962.
JD465134 - Sequence 446158 from Patent EP1572962.
JD547188 - Sequence 528212 from Patent EP1572962.
JD048166 - Sequence 29190 from Patent EP1572962.
JD289514 - Sequence 270538 from Patent EP1572962.
JD071670 - Sequence 52694 from Patent EP1572962.
DQ584127 - Homo sapiens piRNA piR-51239, complete sequence.
JD458562 - Sequence 439586 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0280, NM_015159, NP_055974, Q92567-2, TCRP1
UCSC ID: uc001oty.1
RefSeq Accession: NM_015159
Protein: Q92567-2, splice isoform of Q92567 CCDS: CCDS41689.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015159.1
exon count: 8CDS single in 3' UTR: no RNA size: 1834
ORF size: 708CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1616.00frame shift in genome: no % Coverage: 96.35
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.