Human Gene NCOR1 (uc002gpo.3) Description and Page Index
Description: Homo sapiens nuclear receptor corepressor 1 (NCOR1), transcript variant 1, mRNA. RefSeq Summary (NM_006311): This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]. Transcript (Including UTRs) Position: hg19 chr17:15,933,408-16,118,874 Size: 185,467 Total Exon Count: 46 Strand: - Coding Region Position: hg19 chr17:15,935,610-16,097,883 Size: 162,274 Coding Exon Count: 45
ID:NCOR1_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor corepressor 1; Short=N-CoR; Short=N-CoR1; FUNCTION: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. SUBUNIT: Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains. SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is faciliated with RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and KDM3A. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with HDAC9 (via its catalytic domain). Interacts with CBFA2T3 and HEXIM1. Interacts (via the RRFD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. INTERACTION: Q9UI36:DACH1; NbExp=2; IntAct=EBI-347233, EBI-347111; O15379:HDAC3; NbExp=2; IntAct=EBI-347233, EBI-607682; P10276:RARA; NbExp=3; IntAct=EBI-347233, EBI-413374; Q13263:TRIM28; NbExp=4; IntAct=EBI-347233, EBI-78139; SUBCELLULAR LOCATION: Nucleus (By similarity). DOMAIN: The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3). DOMAIN: The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity). PTM: Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation (By similarity). SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. SIMILARITY: Contains 2 SANT domains. SEQUENCE CAUTION: Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NCOR1 CDC HuGE Published Literature: NCOR1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75376
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0003677 DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0016922 ligand-dependent nuclear receptor binding GO:0035257 nuclear hormone receptor binding GO:0042826 histone deacetylase binding GO:0044212 transcription regulatory region DNA binding GO:0046966 thyroid hormone receptor binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007623 circadian rhythm GO:0019216 regulation of lipid metabolic process GO:0046329 negative regulation of JNK cascade GO:0051225 spindle assembly GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:2000191 regulation of fatty acid transport
BC167431 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone MGC:166905 IMAGE:8860107), complete cds. AF087856 - Homo sapiens nuclear receptor co-repressor mRNA, complete cds. AB028970 - Homo sapiens KIAA1047 mRNA for KIAA1047 protein. AB019524 - Homo sapiens mRNA for nuclear receptor co-repressor, partial cds. AF044209 - Homo sapiens nuclear receptor co-repressor N-CoR mRNA, complete cds. BC172437 - Synthetic construct Homo sapiens clone IMAGE:100069131, MGC:199142 nuclear receptor co-repressor 1 (NCOR1) mRNA, encodes complete protein. AB385422 - Synthetic construct DNA, clone: pF1KA1047, Homo sapiens NCOR1 gene for nuclear receptor corepressor 1, complete cds, without stop codon, in Flexi system. AB028450 - Homo sapiens mRNA for nuclear receptor co-repressor isoform 1, partial cds. AK024136 - Homo sapiens cDNA FLJ14074 fis, clone HEMBB1001869. LF211498 - JP 2014500723-A/19001: Polycomb-Associated Non-Coding RNAs. AF303584 - Homo sapiens NCOR isoform d mRNA, complete cds. AF303585 - Homo sapiens NCOR isoform c mRNA, complete cds. AL137641 - Homo sapiens mRNA; cDNA DKFZp434M075 (from clone DKFZp434M075). JD165058 - Sequence 146082 from Patent EP1572962. AK310405 - Homo sapiens cDNA, FLJ17447. LF380481 - JP 2014500723-A/187984: Polycomb-Associated Non-Coding RNAs. AK295893 - Homo sapiens cDNA FLJ52302 complete cds, highly similar to Nuclear receptor corepressor 1. LF380480 - JP 2014500723-A/187983: Polycomb-Associated Non-Coding RNAs. JD205105 - Sequence 186129 from Patent EP1572962. JD533522 - Sequence 514546 from Patent EP1572962. LF380479 - JP 2014500723-A/187982: Polycomb-Associated Non-Coding RNAs. AB028451 - Homo sapiens mRNA for nuclear receptor co-repressor isoform 2, partial cds. AK302746 - Homo sapiens cDNA FLJ50924 partial cds, highly similar to Nuclear receptor corepressor 1. MA447075 - JP 2018138019-A/19001: Polycomb-Associated Non-Coding RNAs. MA616058 - JP 2018138019-A/187984: Polycomb-Associated Non-Coding RNAs. MA616057 - JP 2018138019-A/187983: Polycomb-Associated Non-Coding RNAs. MA616056 - JP 2018138019-A/187982: Polycomb-Associated Non-Coding RNAs. AF303586 - Homo sapiens NCOR isoform b mRNA, complete cds. BC050594 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:6024800), partial cds. AK307614 - Homo sapiens cDNA, FLJ97562. BC035748 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:5749816), with apparent retained intron. BC026028 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:3836580), partial cds. BC058511 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:5190073), partial cds. BC142648 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:40147982), partial cds. BC068996 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:5474358), partial cds. BC056862 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:3904576), partial cds. BC107772 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:6451988), complete cds. JD276390 - Sequence 257414 from Patent EP1572962. JD309658 - Sequence 290682 from Patent EP1572962. JD542125 - Sequence 523149 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_vdrPathway - Control of Gene Expression by Vitamin D Receptor h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)