Human Gene NGDN (uc001wjy.3) Description and Page Index
  Description: Homo sapiens neuroguidin, EIF4E binding protein (NGDN), transcript variant 1, mRNA.
RefSeq Summary (NM_001042635): Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr14:23,938,898-23,947,402 Size: 8,505 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr14:23,938,925-23,947,235 Size: 8,311 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:23,938,898-23,947,402)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Neuroguidin; AltName: Full=EIF4E-binding protein;
FUNCTION: Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity).
SUBUNIT: Interacts with CPEB1 and EIF4E (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, filopodium (By similarity). Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity).
SIMILARITY: Belongs to the SAS10 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NGDN
CDC HuGE Published Literature: NGDN
Positive Disease Associations: Heart Rate
Related Studies:
  1. Heart Rate
    , , . [PubMed 0]
  2. Heart Rate
    Mark Eijgelsheim et al. Human molecular genetics 2010, Genome-wide association analysis identifies multiple loci related to resting heart rate., Human molecular genetics. [PubMed 20639392]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.13 RPKM in Uterus
Total median expression: 443.85 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.6027-0.207 Picture PostScript Text
3' UTR -26.36167-0.158 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007146 - Sas10/Utp3/C1D

Pfam Domains:
PF04000 - Sas10/Utp3/C1D family

ModBase Predicted Comparative 3D Structure on Q8NEJ9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006417 regulation of translation

Cellular Component:
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0032040 small-subunit processome
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  HQ447612 - Synthetic construct Homo sapiens clone IMAGE:100070958; CCSB013125_01 neuroguidin, EIF4E binding protein (NGDN) gene, encodes complete protein.
KJ898579 - Synthetic construct Homo sapiens clone ccsbBroadEn_07973 NGDN gene, encodes complete protein.
AK124318 - Homo sapiens cDNA FLJ42327 fis, clone TRACH3000515.
AK291875 - Homo sapiens cDNA FLJ75745 complete cds.
BC030817 - Homo sapiens neuroguidin, EIF4E binding protein, mRNA (cDNA clone MGC:22786 IMAGE:4768089), complete cds.
AL050003 - Homo sapiens mRNA; cDNA DKFZp564O092 (from clone DKFZp564O092).
AK022215 - Homo sapiens cDNA FLJ12153 fis, clone MAMMA1000458.
CU689028 - Synthetic construct Homo sapiens gateway clone IMAGE:100022195 5' read NGDN mRNA.
EU832603 - Synthetic construct Homo sapiens clone HAIB:100067632; DKFZo004H0730 neuroguidin, EIF4E binding protein protein (NGDN) gene, encodes complete protein.
EU832521 - Synthetic construct Homo sapiens clone HAIB:100067550; DKFZo008H0729 neuroguidin, EIF4E binding protein protein (NGDN) gene, encodes complete protein.
JD249173 - Sequence 230197 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K760, C14orf120, NGDN_HUMAN, NM_001042635, NP_001036100, Q8NEJ9, Q9Y400
UCSC ID: uc001wjy.3
RefSeq Accession: NM_001042635
Protein: Q8NEJ9 (aka NGDN_HUMAN)
CCDS: CCDS32051.1, CCDS41926.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001042635.1
exon count: 11CDS single in 3' UTR: no RNA size: 1142
ORF size: 948CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2096.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.