Human Gene ZNF740 (uc001scb.4) Description and Page Index
  Description: Homo sapiens zinc finger protein 740 (ZNF740), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:53,574,535-53,584,654 Size: 10,120 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr12:53,575,768-53,581,374 Size: 5,607 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:53,574,535-53,584,654)mRNA (may differ from genome)Protein (193 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 740; AltName: Full=OriLyt TD-element-binding protein 7;
FUNCTION: May be involved in transcriptional regulation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.48 RPKM in Brain - Cerebellum
Total median expression: 452.82 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.50394-0.357 Picture PostScript Text
3' UTR -1254.903280-0.383 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q8NDX6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK292744 - Homo sapiens cDNA FLJ75383 complete cds, highly similar to Homo sapiens zinc finger protein 740, mRNA.
BC053557 - Homo sapiens zinc finger protein 740, mRNA (cDNA clone MGC:61706 IMAGE:6162269), complete cds.
JD489931 - Sequence 470955 from Patent EP1572962.
JD339788 - Sequence 320812 from Patent EP1572962.
JD109296 - Sequence 90320 from Patent EP1572962.
AK091946 - Homo sapiens cDNA FLJ34627 fis, clone KIDNE2015445, weakly similar to Mus musculus transcription factor BFCOL1 mRNA.
JD191341 - Sequence 172365 from Patent EP1572962.
JD267353 - Sequence 248377 from Patent EP1572962.
JD364286 - Sequence 345310 from Patent EP1572962.
JD151122 - Sequence 132146 from Patent EP1572962.
JD400592 - Sequence 381616 from Patent EP1572962.
JD320989 - Sequence 302013 from Patent EP1572962.
JD497289 - Sequence 478313 from Patent EP1572962.
JD226170 - Sequence 207194 from Patent EP1572962.
JD248859 - Sequence 229883 from Patent EP1572962.
JD415307 - Sequence 396331 from Patent EP1572962.
JD049397 - Sequence 30421 from Patent EP1572962.
JD506151 - Sequence 487175 from Patent EP1572962.
JD237995 - Sequence 219019 from Patent EP1572962.
JD487402 - Sequence 468426 from Patent EP1572962.
JD561465 - Sequence 542489 from Patent EP1572962.
JD276173 - Sequence 257197 from Patent EP1572962.
JD122819 - Sequence 103843 from Patent EP1572962.
JD037600 - Sequence 18624 from Patent EP1572962.
JD511401 - Sequence 492425 from Patent EP1572962.
JD225530 - Sequence 206554 from Patent EP1572962.
JD385714 - Sequence 366738 from Patent EP1572962.
JD556976 - Sequence 538000 from Patent EP1572962.
JD254327 - Sequence 235351 from Patent EP1572962.
JD423547 - Sequence 404571 from Patent EP1572962.
AF086252 - Homo sapiens full length insert cDNA clone ZD40B09.
JD091840 - Sequence 72864 from Patent EP1572962.
JD070375 - Sequence 51399 from Patent EP1572962.
JD061646 - Sequence 42670 from Patent EP1572962.
JD039530 - Sequence 20554 from Patent EP1572962.
JD214334 - Sequence 195358 from Patent EP1572962.
JD124492 - Sequence 105516 from Patent EP1572962.
JD263641 - Sequence 244665 from Patent EP1572962.
JD252236 - Sequence 233260 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8NDX6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9M9, NM_001004304, NP_001004304, Q8NDX6, TB7, ZN740_HUMAN
UCSC ID: uc001scb.4
RefSeq Accession: NM_001004304
Protein: Q8NDX6 (aka ZN740_HUMAN)
CCDS: CCDS44896.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001004304.3
exon count: 7CDS single in 3' UTR: no RNA size: 4256
ORF size: 582CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1313.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.