Human Gene PPP5D1 (uc021uwg.1) Description and Page Index
  Description: Homo sapiens PPP5 tetratricopeptide repeat domain containing 1 (PPP5D1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:46,984,045-47,104,457 Size: 120,413 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr19:46,984,641-47,104,226 Size: 119,586 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:46,984,045-47,104,457)mRNA (may differ from genome)Protein (137 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHGNC
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: PP5D1_HUMAN
DESCRIPTION: RecName: Full=Protein PPP5D1; AltName: Full=PPP5 TPR repeat domain-containing protein 1;
MISCELLANEOUS: Shares sequence similarity with serine/threonine- protein phosphatase PPP5C. However, it is much shorter and does not contain the phosphatase catalytic region.
SIMILARITY: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.97 RPKM in Brain - Hypothalamus
Total median expression: 16.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -97.40231-0.422 Picture PostScript Text
3' UTR -135.70596-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013235 - PPP_dom

Pfam Domains:
PF08321 - PPP5 TPR repeat region

ModBase Predicted Comparative 3D Structure on E7EU14
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK094504 - Homo sapiens cDNA FLJ37185 fis, clone BRALZ2001743, moderately similar to Serine/threonine-protein phosphatase 5 (EC 3.1.3.16).
JD491701 - Sequence 472725 from Patent EP1572962.
AK098294 - Homo sapiens cDNA FLJ40975 fis, clone UTERU2013502.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KSW5, E7EU14, NM_001205281, NP_001192210, PP5D1_HUMAN
UCSC ID: uc021uwg.1
RefSeq Accession: NM_001205281
Protein: E7EU14 (aka PP5D1_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001205281.1
exon count: 4CDS single in 3' UTR: no RNA size: 1257
ORF size: 414CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 971.00frame shift in genome: no % Coverage: 98.73
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.