Human Gene RAB41 (uc010nkv.3) Description and Page Index
  Description: Homo sapiens RAB41, member RAS oncogene family (RAB41), mRNA.
RefSeq Summary (NM_001032726): This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]. ##Evidence-Data-START## Transcript exon combination :: BC117239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2158188 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: hg19 chrX:69,502,022-69,504,852 Size: 2,831 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chrX:69,502,068-69,504,493 Size: 2,426 Coding Exon Count: 8 

Page IndexSequence and LinksGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:69,502,022-69,504,852)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIPubMed
ReactomeStanford SOURCETreefamUniProtKB

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.20 RPKM in Testis
Total median expression: 22.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.5046-0.359 Picture PostScript Text
3' UTR -73.31359-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q5JT25-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Descriptions from all associated GenBank mRNAs
  BC117239 - Homo sapiens RAB41, member RAS oncogene family, mRNA (cDNA clone MGC:150848 IMAGE:40125790), complete cds.
BC143888 - Homo sapiens cDNA clone IMAGE:9052405, containing frame-shift errors.
HQ258116 - Synthetic construct Homo sapiens clone IMAGE:100072425 Unknown protein gene, encodes complete protein.
KJ896115 - Synthetic construct Homo sapiens clone ccsbBroadEn_05509 RAB41 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5JT25 (Reactome details) participates in the following event(s):

R-HSA-8849748 The COG complex binds RABs at the Golgi membrane
R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-6811438 Intra-Golgi traffic
R-HSA-8873719 RAB geranylgeranylation
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-597592 Post-translational protein modification
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001032726, NP_001027898, Q5JT25-2
UCSC ID: uc010nkv.3
RefSeq Accession: NM_001032726
Protein: Q5JT25-2, splice isoform of Q5JT25 CCDS: CCDS35322.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001032726.2
exon count: 8CDS single in 3' UTR: no RNA size: 1077
ORF size: 666CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1319.00frame shift in genome: no % Coverage: 99.44
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.