Human Gene RAB41 (uc010nkv.3) Description and Page Index
Description: Homo sapiens RAB41, member RAS oncogene family (RAB41), mRNA. RefSeq Summary (NM_001032726): This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]. ##Evidence-Data-START## Transcript exon combination :: BC117239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: hg19 chrX:69,502,022-69,504,852 Size: 2,831 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chrX:69,502,068-69,504,493 Size: 2,426 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00025 - ADP-ribosylation factor family PF00071 - Ras family PF04670 - Gtr1/RagA G protein conserved region PF08477 - Ras of Complex, Roc, domain of DAPkinase
ModBase Predicted Comparative 3D Structure on Q5JT25-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.