ID:ZN425_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 425; FUNCTION: Acts as a transcriptional repressor. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus. DEVELOPMENTAL STAGE: Expressed in 30 days old embryos. Almost undetectable in 60 days old embryos and in adults. DOMAIN: The C2H2 domain is necessary for the transcriptional repression. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 19 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6IV72
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045892 negative regulation of transcription, DNA-templated