Human Gene KBTBD3 (uc001pjb.3) Description and Page Index
  Description: Homo sapiens kelch repeat and BTB (POZ) domain containing 3 (KBTBD3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:105,921,825-105,948,465 Size: 26,641 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr11:105,923,577-105,929,824 Size: 6,248 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:105,921,825-105,948,465)mRNA (may differ from genome)Protein (612 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Kelch repeat and BTB domain-containing protein 3; AltName: Full=BTB and kelch domain-containing protein 3;
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 5 Kelch repeats.
SEQUENCE CAUTION: Sequence=AAI17467.1; Type=Erroneous initiation; Sequence=CAE45804.1; Type=Erroneous initiation; Sequence=EAW67073.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.48 RPKM in Pituitary
Total median expression: 64.82 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -185.00439-0.421 Picture PostScript Text
3' UTR -382.401752-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR017096 - Kelch-like_gigaxonin
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07707 - BTB And C-terminal Kelch

SCOP Domains:
50965 - Galactose oxidase, central domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8NAB2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination

Cellular Component:
GO:0031463 Cul3-RING ubiquitin ligase complex

-  Descriptions from all associated GenBank mRNAs
  BX647830 - Homo sapiens mRNA; cDNA DKFZp779E1617 (from clone DKFZp779E1617).
BX640672 - Homo sapiens mRNA; cDNA DKFZp686D14128 (from clone DKFZp686D14128).
LF384507 - JP 2014500723-A/192010: Polycomb-Associated Non-Coding RNAs.
AK055247 - Homo sapiens cDNA FLJ30685 fis, clone FCBBF2000276.
JD082373 - Sequence 63397 from Patent EP1572962.
JD496814 - Sequence 477838 from Patent EP1572962.
JD237222 - Sequence 218246 from Patent EP1572962.
BC117466 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone MGC:151075 IMAGE:40126017), complete cds.
AK092993 - Homo sapiens cDNA FLJ35674 fis, clone SPLEN2018299.
AX747842 - Sequence 1367 from Patent EP1308459.
JD449908 - Sequence 430932 from Patent EP1572962.
JD551742 - Sequence 532766 from Patent EP1572962.
AK289915 - Homo sapiens cDNA FLJ76341 complete cds, highly similar to Homo sapiens kelch repeat and BTB (POZ) domain containing 3 (KBTBD3), transcript variant 1, mRNA.
JD553457 - Sequence 534481 from Patent EP1572962.
KJ895571 - Synthetic construct Homo sapiens clone ccsbBroadEn_04965 KBTBD3 gene, encodes complete protein.
EU831921 - Synthetic construct Homo sapiens clone HAIB:100066950; DKFZo008B0923 kelch repeat and BTB (POZ) domain containing 3 protein (KBTBD3) gene, encodes complete protein.
GQ891308 - Homo sapiens clone HEL-S-31a epididymis secretory sperm binding protein mRNA, complete cds.
EU832015 - Synthetic construct Homo sapiens clone HAIB:100067044; DKFZo004B0924 kelch repeat and BTB (POZ) domain containing 3 protein (KBTBD3) gene, encodes complete protein.
HQ258322 - Synthetic construct Homo sapiens clone IMAGE:100072631 kelch repeat and BTB (POZ) domain containing 3 (KBTBD3), transcript variant 2 (KBTBD3) gene, encodes complete protein.
LF375532 - JP 2014500723-A/183035: Polycomb-Associated Non-Coding RNAs.
BC047311 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone IMAGE:5178766), partial cds.
BC107691 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone IMAGE:4287155), partial cds.
BC062667 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone IMAGE:6592764).
LF375531 - JP 2014500723-A/183034: Polycomb-Associated Non-Coding RNAs.
AK124540 - Homo sapiens cDNA FLJ42549 fis, clone BRACE3004998.
LF375529 - JP 2014500723-A/183032: Polycomb-Associated Non-Coding RNAs.
CU677696 - Synthetic construct Homo sapiens gateway clone IMAGE:100017005 3' read AASDHPPT mRNA.
MA620084 - JP 2018138019-A/192010: Polycomb-Associated Non-Coding RNAs.
MA611109 - JP 2018138019-A/183035: Polycomb-Associated Non-Coding RNAs.
MA611108 - JP 2018138019-A/183034: Polycomb-Associated Non-Coding RNAs.
MA611106 - JP 2018138019-A/183032: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BKLHD3, KBTB3_HUMAN, NM_152433, NP_940841, Q6N066, Q86X38, Q8NAB2, Q96NK5
UCSC ID: uc001pjb.3
RefSeq Accession: NM_152433
Protein: Q8NAB2 (aka KBTB3_HUMAN or KBT3_HUMAN)
CCDS: CCDS8334.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_152433.3
exon count: 3CDS single in 3' UTR: no RNA size: 4030
ORF size: 1839CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3639.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.