Human Gene FGFBP3 (uc001khq.4) Description and Page Index
  Description: Homo sapiens fibroblast growth factor binding protein 3 (FGFBP3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:93,666,345-93,669,258 Size: 2,914 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr10:93,667,950-93,668,726 Size: 777 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:93,666,345-93,669,258)mRNA (may differ from genome)Protein (258 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FGFP3_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor-binding protein 3; Short=FGF-BP3; Short=FGF-binding protein 3; Short=FGFBP-3; Flags: Precursor;
SUBUNIT: Interacts with FGF1.
SUBCELLULAR LOCATION: Secreted (Probable).
SIMILARITY: Belongs to the fibroblast growth factor-binding protein family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D014212 Tretinoin
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
  • D004041 Dietary Fats
  • D011794 Quercetin
  • D014635 Valproic Acid
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.61 RPKM in Brain - Hypothalamus
Total median expression: 69.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.60182-0.300 Picture PostScript Text
3' UTR -505.911605-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010510 - FGF1-bd

Pfam Domains:
PF06473 - FGF binding protein 1 (FGF-BP1)

ModBase Predicted Comparative 3D Structure on Q8TAT2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
GO:0019838 growth factor binding

Biological Process:
GO:0043117 positive regulation of vascular permeability
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0031012 extracellular matrix


-  Descriptions from all associated GenBank mRNAs
  AK075410 - Homo sapiens cDNA PSEC0101 fis, clone NT2RP2003115.
JD172345 - Sequence 153369 from Patent EP1572962.
JD224173 - Sequence 205197 from Patent EP1572962.
LF211308 - JP 2014500723-A/18811: Polycomb-Associated Non-Coding RNAs.
JD499351 - Sequence 480375 from Patent EP1572962.
JD331202 - Sequence 312226 from Patent EP1572962.
JD347533 - Sequence 328557 from Patent EP1572962.
JD518738 - Sequence 499762 from Patent EP1572962.
JD554265 - Sequence 535289 from Patent EP1572962.
JD553247 - Sequence 534271 from Patent EP1572962.
JD357303 - Sequence 338327 from Patent EP1572962.
JD060403 - Sequence 41427 from Patent EP1572962.
JD546803 - Sequence 527827 from Patent EP1572962.
JD166100 - Sequence 147124 from Patent EP1572962.
JD058739 - Sequence 39763 from Patent EP1572962.
JD180357 - Sequence 161381 from Patent EP1572962.
JD102872 - Sequence 83896 from Patent EP1572962.
JD059883 - Sequence 40907 from Patent EP1572962.
JD074603 - Sequence 55627 from Patent EP1572962.
JD119399 - Sequence 100423 from Patent EP1572962.
JD213846 - Sequence 194870 from Patent EP1572962.
JD159992 - Sequence 141016 from Patent EP1572962.
JD526890 - Sequence 507914 from Patent EP1572962.
JD494069 - Sequence 475093 from Patent EP1572962.
JD219801 - Sequence 200825 from Patent EP1572962.
JD420021 - Sequence 401045 from Patent EP1572962.
JD174649 - Sequence 155673 from Patent EP1572962.
JD242050 - Sequence 223074 from Patent EP1572962.
JD349311 - Sequence 330335 from Patent EP1572962.
JD348962 - Sequence 329986 from Patent EP1572962.
JD344620 - Sequence 325644 from Patent EP1572962.
BC025966 - Homo sapiens fibroblast growth factor binding protein 3, mRNA (cDNA clone MGC:39320 IMAGE:4895171), complete cds.
LF345471 - JP 2014500723-A/152974: Polycomb-Associated Non-Coding RNAs.
JD168118 - Sequence 149142 from Patent EP1572962.
LF345472 - JP 2014500723-A/152975: Polycomb-Associated Non-Coding RNAs.
JD045717 - Sequence 26741 from Patent EP1572962.
JD045276 - Sequence 26300 from Patent EP1572962.
JD221047 - Sequence 202071 from Patent EP1572962.
JD078184 - Sequence 59208 from Patent EP1572962.
JD242102 - Sequence 223126 from Patent EP1572962.
JD552173 - Sequence 533197 from Patent EP1572962.
JD395261 - Sequence 376285 from Patent EP1572962.
JD537051 - Sequence 518075 from Patent EP1572962.
JD435170 - Sequence 416194 from Patent EP1572962.
DQ503576 - Homo sapiens fibroblast growth factor binding protein 3 mRNA, complete cds.
AK315427 - Homo sapiens cDNA, FLJ96482.
AB464522 - Synthetic construct DNA, clone: pF1KB8778, Homo sapiens FGFBP3 gene for fibroblast growth factor binding protein 3, without stop codon, in Flexi system.
JD202739 - Sequence 183763 from Patent EP1572962.
JD488272 - Sequence 469296 from Patent EP1572962.
JD410871 - Sequence 391895 from Patent EP1572962.
JD536053 - Sequence 517077 from Patent EP1572962.
MA581048 - JP 2018138019-A/152974: Polycomb-Associated Non-Coding RNAs.
MA581049 - JP 2018138019-A/152975: Polycomb-Associated Non-Coding RNAs.
MA446885 - JP 2018138019-A/18811: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TAT2 (Reactome details) participates in the following event(s):

R-HSA-5656070 FGFBPs bind FGFs
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654738 Signaling by FGFR2
R-HSA-190236 Signaling by FGFR
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD68, C10orf13, FGFP3_HUMAN, NM_152429, NP_689642, PSEC0101, Q8NBN0, Q8TAT2
UCSC ID: uc001khq.4
RefSeq Accession: NM_152429
Protein: Q8TAT2 (aka FGFP3_HUMAN)
CCDS: CCDS7418.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152429.4
exon count: 2CDS single in 3' UTR: no RNA size: 2564
ORF size: 777CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1671.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.