Human Gene MED20 (uc003ork.3) Description and Page Index
Description: Homo sapiens mediator complex subunit 20 (MED20), mRNA. RefSeq Summary (NM_004275): This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]. Transcript (Including UTRs) Position: hg19 chr6:41,873,092-41,888,877 Size: 15,786 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr6:41,874,810-41,888,756 Size: 13,947 Coding Exon Count: 4
ID:MED20_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 20; AltName: Full=Mediator complex subunit 20; AltName: Full=TRF-proximal protein homolog; Short=hTRFP; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. INTERACTION: Q9NX70:MED29; NbExp=5; IntAct=EBI-394644, EBI-394656; SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the Mediator complex subunit 20 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08612 - TATA-binding related factor (TRF) of subunit 20 of Mediator complex
ModBase Predicted Comparative 3D Structure on Q9H944
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001104 RNA polymerase II transcription cofactor activity GO:0003713 transcription coactivator activity GO:0003899 DNA-directed 5'-3' RNA polymerase activity GO:0005515 protein binding GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0016567 protein ubiquitination GO:0035914 skeletal muscle cell differentiation