Human Gene ZNF134 (uc002qpn.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 134 (ZNF134), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:58,125,830-58,133,636 Size: 7,807 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:58,130,837-58,132,771 Size: 1,935 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:58,125,830-58,133,636)mRNA (may differ from genome)Protein (427 aa)
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OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZN134_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 134;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.95 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 207.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.4099-0.347 Picture PostScript Text
3' UTR -267.50865-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on P52741
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK291763 - Homo sapiens cDNA FLJ75728 complete cds, highly similar to Homo sapiens zinc finger protein 134 (clone pHZ-15) (ZNF134), mRNA.
BC042636 - Homo sapiens zinc finger protein 134, mRNA (cDNA clone MGC:41871 IMAGE:4826076), complete cds.
BC011646 - Homo sapiens zinc finger protein 134, mRNA (cDNA clone IMAGE:4300721), partial cds.
U09412 - Human zinc finger protein ZNF134 mRNA, complete cds.
BC021280 - Homo sapiens zinc finger protein 134, mRNA (cDNA clone IMAGE:4908077), partial cds.
BC112294 - Homo sapiens zinc finger protein 134, mRNA (cDNA clone MGC:138499 IMAGE:8327762), complete cds.
BC113410 - Homo sapiens zinc finger protein 134, mRNA (cDNA clone MGC:141970 IMAGE:8322462), complete cds.
JD355999 - Sequence 337023 from Patent EP1572962.
AB587361 - Synthetic construct DNA, clone: pF1KB0966, Homo sapiens ZNF134 gene for zinc finger protein 134, without stop codon, in Flexi system.
EU832473 - Synthetic construct Homo sapiens clone HAIB:100067502; DKFZo008C1129 zinc finger protein 134 protein (ZNF134) gene, encodes complete protein.
EU832552 - Synthetic construct Homo sapiens clone HAIB:100067581; DKFZo004C1130 zinc finger protein 134 protein (ZNF134) gene, encodes complete protein.
HQ258404 - Synthetic construct Homo sapiens clone IMAGE:100072833 zinc finger protein 134 (ZNF134) gene, encodes complete protein.
KJ892414 - Synthetic construct Homo sapiens clone ccsbBroadEn_01808 ZNF134 gene, encodes complete protein.
EU446916 - Synthetic construct Homo sapiens clone IMAGE:100070255; IMAGE:100012125; FLH257358.01L zinc finger protein 134 (ZNF134) gene, encodes complete protein.
JD331709 - Sequence 312733 from Patent EP1572962.
AB209847 - Homo sapiens mRNA for zinc finger protein 211 isoform 2 variant protein.
AF024704 - Homo sapiens clone L4-15 zinc finger protein mRNA, partial cds.
JD312627 - Sequence 293651 from Patent EP1572962.
JD512900 - Sequence 493924 from Patent EP1572962.
JD316233 - Sequence 297257 from Patent EP1572962.
JD485785 - Sequence 466809 from Patent EP1572962.
JD446113 - Sequence 427137 from Patent EP1572962.
JD556568 - Sequence 537592 from Patent EP1572962.
JD082108 - Sequence 63132 from Patent EP1572962.
JD501693 - Sequence 482717 from Patent EP1572962.
JD105073 - Sequence 86097 from Patent EP1572962.
JD251112 - Sequence 232136 from Patent EP1572962.
JD099877 - Sequence 80901 from Patent EP1572962.
JD322834 - Sequence 303858 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_003435, NP_003426, P52741, Q9Y4B2, ZN134_HUMAN
UCSC ID: uc002qpn.2
RefSeq Accession: NM_003435
Protein: P52741 (aka ZN134_HUMAN or Z134_HUMAN)
CCDS: CCDS42638.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003435.3
exon count: 3CDS single in 3' UTR: no RNA size: 2248
ORF size: 1284CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2717.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.