Human Gene SOCS4 (uc001xbp.3) Description and Page Index
Description: Homo sapiens suppressor of cytokine signaling 4 (SOCS4), transcript variant 2, mRNA. RefSeq Summary (NM_080867): The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr14:55,493,844-55,516,206 Size: 22,363 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr14:55,509,760-55,511,082 Size: 1,323 Coding Exon Count: 1
ID:SOCS4_HUMAN DESCRIPTION: RecName: Full=Suppressor of cytokine signaling 4; Short=SOCS-4; AltName: Full=Suppressor of cytokine signaling 7; Short=SOCS-7; FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. PATHWAY: Protein modification; protein ubiquitination. INDUCTION: Up-regulated by EGF. DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 1 SOCS box domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SOCS4 CDC HuGE Published Literature: SOCS4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXH5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007175 negative regulation of epidermal growth factor-activated receptor activity GO:0009968 negative regulation of signal transduction GO:0016567 protein ubiquitination GO:0019221 cytokine-mediated signaling pathway GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0035556 intracellular signal transduction GO:0040008 regulation of growth GO:0046426 negative regulation of JAK-STAT cascade