Human Gene ABHD13 (uc001vqq.3) Description and Page Index
  Description: Homo sapiens abhydrolase domain containing 13 (ABHD13), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr13:108,870,763-108,886,603 Size: 15,841 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr13:108,881,567-108,882,580 Size: 1,014 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:108,870,763-108,886,603)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ABHDD_HUMAN
DESCRIPTION: RecName: Full=Alpha/beta hydrolase domain-containing protein 13; Short=Abhydrolase domain-containing protein 13; EC=3.-.-.-;
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the serine esterase family.
SEQUENCE CAUTION: Sequence=AAH70226.1; Type=Erroneous initiation; Sequence=AK075195; Type=Erroneous termination; Positions=167; Note=Translated as Leu; Sequence=BAB55387.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ABHD13
CDC HuGE Published Literature: ABHD13
Positive Disease Associations: Attention deficit hyperactivity disorder and conduct disorder
Related Studies:
  1. Attention deficit hyperactivity disorder and conduct disorder
    Anney ,et al. 2008, Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study, American journal of medical genetics. Part B, Neuropsychiatric genetics 2008 147B- 8 : 1369-78. [PubMed 18951430]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 165.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.40265-0.477 Picture PostScript Text
3' UTR -964.494023-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00561 - alpha/beta hydrolase fold
PF05448 - Acetyl xylan esterase (AXE1)
PF12146 - Serine aminopeptidase, S33

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q7L211
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0002084 protein depalmitoylation

Cellular Component:
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032839 dendrite cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF208024 - JP 2014500723-A/15527: Polycomb-Associated Non-Coding RNAs.
AK075195 - Homo sapiens cDNA FLJ90714 fis, clone PLACE1008359.
BC022566 - Homo sapiens abhydrolase domain containing 13, mRNA (cDNA clone MGC:27058 IMAGE:4811611), complete cds.
LF371066 - JP 2014500723-A/178569: Polycomb-Associated Non-Coding RNAs.
AK124864 - Homo sapiens cDNA FLJ42874 fis, clone BRHIP2026288, weakly similar to Protein bem46.
BX647428 - Homo sapiens mRNA; cDNA DKFZp686P09144 (from clone DKFZp686P09144).
LF371069 - JP 2014500723-A/178572: Polycomb-Associated Non-Coding RNAs.
BC070226 - Homo sapiens abhydrolase domain containing 13, mRNA (cDNA clone MGC:88207 IMAGE:6716889), complete cds.
AK027812 - Homo sapiens cDNA FLJ14906 fis, clone PLACE1005890, weakly similar to BEM46 PROTEIN.
KJ903495 - Synthetic construct Homo sapiens clone ccsbBroadEn_12889 ABHD13 gene, encodes complete protein.
LF371070 - JP 2014500723-A/178573: Polycomb-Associated Non-Coding RNAs.
LF371071 - JP 2014500723-A/178574: Polycomb-Associated Non-Coding RNAs.
LF371072 - JP 2014500723-A/178575: Polycomb-Associated Non-Coding RNAs.
LF371073 - JP 2014500723-A/178576: Polycomb-Associated Non-Coding RNAs.
JD087694 - Sequence 68718 from Patent EP1572962.
JD486838 - Sequence 467862 from Patent EP1572962.
JD291111 - Sequence 272135 from Patent EP1572962.
JD490922 - Sequence 471946 from Patent EP1572962.
LF371074 - JP 2014500723-A/178577: Polycomb-Associated Non-Coding RNAs.
JD094563 - Sequence 75587 from Patent EP1572962.
JD206382 - Sequence 187406 from Patent EP1572962.
JD239443 - Sequence 220467 from Patent EP1572962.
JD103612 - Sequence 84636 from Patent EP1572962.
BC018608 - Homo sapiens abhydrolase domain containing 13, mRNA (cDNA clone IMAGE:3918528).
JD114682 - Sequence 95706 from Patent EP1572962.
MA606643 - JP 2018138019-A/178569: Polycomb-Associated Non-Coding RNAs.
MA606646 - JP 2018138019-A/178572: Polycomb-Associated Non-Coding RNAs.
MA606647 - JP 2018138019-A/178573: Polycomb-Associated Non-Coding RNAs.
MA606648 - JP 2018138019-A/178574: Polycomb-Associated Non-Coding RNAs.
MA606649 - JP 2018138019-A/178575: Polycomb-Associated Non-Coding RNAs.
MA606650 - JP 2018138019-A/178576: Polycomb-Associated Non-Coding RNAs.
MA606651 - JP 2018138019-A/178577: Polycomb-Associated Non-Coding RNAs.
MA443601 - JP 2018138019-A/15527: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ABHDD_HUMAN, B3KWE7, C13orf6, NM_032859, NP_116248, Q7L211, Q8NBW1, Q96JX9
UCSC ID: uc001vqq.3
RefSeq Accession: NM_032859
Protein: Q7L211 (aka ABHDD_HUMAN)
CCDS: CCDS32007.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032859.2
exon count: 2CDS single in 3' UTR: no RNA size: 5316
ORF size: 1014CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2007.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.