Human Gene CRISPLD2 (uc010voh.1) Description and Page Index
  Description: Homo sapiens cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:84,853,587-84,943,116 Size: 89,530 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr16:84,872,102-84,940,248 Size: 68,147 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:84,853,587-84,943,116)mRNA (may differ from genome)Protein (497 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Cysteine-rich secretory protein LCCL domain-containing 2; AltName: Full=Cysteine-rich secretory protein 11; Short=CRISP-11; AltName: Full=LCCL domain-containing cysteine-rich secretory protein 2; Flags: Precursor;
FUNCTION: Promotes matrix assembly (By similarity).
SUBUNIT: Binds to heparin, dermatan sulfate and chondroitin sulfate (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the CRISP family.
SIMILARITY: Contains 2 LCCL domains.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CRISPLD2
CDC HuGE Published Literature: CRISPLD2
Positive Disease Associations: Body Height , height
Related Studies:
  1. Body Height
    Daniel F Gudbjartsson et al. Nature genetics 2008, Many sequence variants affecting diversity of adult human height., Nature genetics. [PubMed 18391951]
  2. height
    Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15. [PubMed 18391951]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 100.11 RPKM in Fallopian Tube
Total median expression: 1087.68 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -98.20227-0.433 Picture PostScript Text
3' UTR -930.782868-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001283 - Allrgn_V5/Tpx1
IPR018244 - Allrgn_V5/Tpx1_CS
IPR014044 - CAP_domain
IPR004043 - LCCL

Pfam Domains:
PF00188 - Cysteine-rich secretory protein family
PF03815 - LCCL domain

SCOP Domains:
55797 - PR-1-like
69848 - LCCL domain

ModBase Predicted Comparative 3D Structure on Q9H0B8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding

Biological Process:
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0043312 neutrophil degranulation
GO:0060325 face morphogenesis

Cellular Component:
GO:0005576 extracellular region
GO:0030133 transport vesicle
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

-  Descriptions from all associated GenBank mRNAs
  HM005620 - Homo sapiens clone HTL-S-207a testis secretory sperm-binding protein Li 207a mRNA, complete cds.
LF384477 - JP 2014500723-A/191980: Polycomb-Associated Non-Coding RNAs.
AY358790 - Homo sapiens clone DNA131590 trypsin inhibitor (UNQ2914) mRNA, complete cds.
AK303887 - Homo sapiens cDNA FLJ61040 complete cds, moderately similar to Homo sapiens cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2), mRNA.
AL136861 - Homo sapiens mRNA; cDNA DKFZp434B044 (from clone DKFZp434B044).
AB587512 - Synthetic construct DNA, clone: pF1KE0001, Homo sapiens CRISPLD2 gene for cysteine-rich secretory protein LCCL domain containing 2, without stop codon, in Flexi system.
AM393137 - Synthetic construct Homo sapiens clone IMAGE:100001654 for hypothetical protein (CRISPLD2 gene).
MA620054 - JP 2018138019-A/191980: Polycomb-Associated Non-Coding RNAs.
AK308396 - Homo sapiens cDNA, FLJ98344.
AY358413 - Homo sapiens clone DNA59853 trypsin inhibitor (UNQ2914) mRNA, complete cds.
BC063012 - Homo sapiens cysteine-rich secretory protein LCCL domain containing 2, mRNA (cDNA clone MGC:74865 IMAGE:5217820), complete cds.
BC007689 - Homo sapiens cysteine-rich secretory protein LCCL domain containing 2, mRNA (cDNA clone IMAGE:3953885), complete cds.
AK027395 - Homo sapiens cDNA FLJ14489 fis, clone MAMMA1002881, weakly similar to GLIOMA PATHOGENESIS-RELATED PROTEIN.
JD464950 - Sequence 445974 from Patent EP1572962.
JD523704 - Sequence 504728 from Patent EP1572962.
CU687626 - Synthetic construct Homo sapiens gateway clone IMAGE:100021782 5' read CRISPLD2 mRNA.
KJ903358 - Synthetic construct Homo sapiens clone ccsbBroadEn_12752 CRISPLD2 gene, encodes complete protein.
LF374941 - JP 2014500723-A/182444: Polycomb-Associated Non-Coding RNAs.
MA610518 - JP 2018138019-A/182444: Polycomb-Associated Non-Coding RNAs.
JD066436 - Sequence 47460 from Patent EP1572962.
JD220130 - Sequence 201154 from Patent EP1572962.
JD154948 - Sequence 135972 from Patent EP1572962.
JD135474 - Sequence 116498 from Patent EP1572962.
JD563399 - Sequence 544423 from Patent EP1572962.
JD064405 - Sequence 45429 from Patent EP1572962.
JD120367 - Sequence 101391 from Patent EP1572962.
AK056839 - Homo sapiens cDNA FLJ32277 fis, clone PROST2000138.
JD439646 - Sequence 420670 from Patent EP1572962.
JD464563 - Sequence 445587 from Patent EP1572962.
JD331329 - Sequence 312353 from Patent EP1572962.
JD295808 - Sequence 276832 from Patent EP1572962.
JD163139 - Sequence 144163 from Patent EP1572962.
JD265686 - Sequence 246710 from Patent EP1572962.
BC018643 - Homo sapiens cysteine-rich secretory protein LCCL domain containing 2, mRNA (cDNA clone IMAGE:3837715).
JD302503 - Sequence 283527 from Patent EP1572962.
JD507715 - Sequence 488739 from Patent EP1572962.
JD552227 - Sequence 533251 from Patent EP1572962.
JD315923 - Sequence 296947 from Patent EP1572962.
JD562886 - Sequence 543910 from Patent EP1572962.
JD080047 - Sequence 61071 from Patent EP1572962.
JD174203 - Sequence 155227 from Patent EP1572962.
JD385371 - Sequence 366395 from Patent EP1572962.
JD204324 - Sequence 185348 from Patent EP1572962.
JD256299 - Sequence 237323 from Patent EP1572962.
JD138002 - Sequence 119026 from Patent EP1572962.
JD326005 - Sequence 307029 from Patent EP1572962.
JD153574 - Sequence 134598 from Patent EP1572962.
JD428242 - Sequence 409266 from Patent EP1572962.
JD550241 - Sequence 531265 from Patent EP1572962.
JD234069 - Sequence 215093 from Patent EP1572962.
JD234070 - Sequence 215094 from Patent EP1572962.
JD293089 - Sequence 274113 from Patent EP1572962.
JD293090 - Sequence 274114 from Patent EP1572962.
JD507633 - Sequence 488657 from Patent EP1572962.
JD271548 - Sequence 252572 from Patent EP1572962.
JD396155 - Sequence 377179 from Patent EP1572962.
JD069845 - Sequence 50869 from Patent EP1572962.
JD069846 - Sequence 50870 from Patent EP1572962.
JD506001 - Sequence 487025 from Patent EP1572962.
JD506002 - Sequence 487026 from Patent EP1572962.
JD341408 - Sequence 322432 from Patent EP1572962.
JD242899 - Sequence 223923 from Patent EP1572962.
JD064624 - Sequence 45648 from Patent EP1572962.
JD490200 - Sequence 471224 from Patent EP1572962.
JD490201 - Sequence 471225 from Patent EP1572962.
JD342306 - Sequence 323330 from Patent EP1572962.
JD424238 - Sequence 405262 from Patent EP1572962.
JD522107 - Sequence 503131 from Patent EP1572962.
JD435531 - Sequence 416555 from Patent EP1572962.
JD560772 - Sequence 541796 from Patent EP1572962.
JD560774 - Sequence 541798 from Patent EP1572962.
JD560773 - Sequence 541797 from Patent EP1572962.
JD476934 - Sequence 457958 from Patent EP1572962.
JD476933 - Sequence 457957 from Patent EP1572962.
JD322860 - Sequence 303884 from Patent EP1572962.
JD543905 - Sequence 524929 from Patent EP1572962.
JD111492 - Sequence 92516 from Patent EP1572962.
JD555865 - Sequence 536889 from Patent EP1572962.
JD506509 - Sequence 487533 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H0B8 (Reactome details) participates in the following event(s):

R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CRISP11, CRLD2_HUMAN, D3DUM0, LCRISP2, NM_031476, NP_113664, Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61, Q9H0B8, UNQ2914/PRO1156/PRO9783
UCSC ID: uc010voh.1
RefSeq Accession: NM_031476
Protein: Q9H0B8 (aka CRLD2_HUMAN)
CCDS: CCDS10949.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_031476.3
exon count: 15CDS single in 3' UTR: no RNA size: 4607
ORF size: 1494CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3188.00frame shift in genome: no % Coverage: 99.61
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.