Human Gene HDAC7 (uc010slo.2) Description and Page Index
Description: Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 1, mRNA. RefSeq Summary (NM_015401): Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:48,176,507-48,213,763 Size: 37,257 Total Exon Count: 26 Strand: - Coding Region Position: hg19 chr12:48,177,624-48,213,568 Size: 35,945 Coding Exon Count: 26
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WUI4-5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK225910 - Homo sapiens mRNA for histone deacetylase 7A isoform a variant, clone: FCC119B01. AK026767 - Homo sapiens cDNA: FLJ23114 fis, clone LNG07880. BC006453 - Homo sapiens histone deacetylase 7, mRNA (cDNA clone IMAGE:4054348), partial cds. BC020505 - Homo sapiens histone deacetylase 7, mRNA (cDNA clone IMAGE:3851375), partial cds. AL117455 - Homo sapiens mRNA; cDNA DKFZp586J0917 (from clone DKFZp586J0917); partial cds. BC064840 - Homo sapiens histone deacetylase 7, mRNA (cDNA clone MGC:74915 IMAGE:6179239), complete cds. AK001032 - Homo sapiens cDNA FLJ10170 fis, clone HEMBA1003690, weakly similar to HISTONE DEACETYLASE HDA1. AK122588 - Homo sapiens mRNA for FLJ00413 protein. AK128383 - Homo sapiens cDNA FLJ46526 fis, clone THYMU3034671, highly similar to Histone deacetylase 7a. AK001190 - Homo sapiens cDNA FLJ10328 fis, clone NT2RM2000588, weakly similar to HISTONE DEACETYLASE HDA1. AK024469 - Homo sapiens mRNA for FLJ00062 protein, partial cds. AY321367 - Homo sapiens histone deacetylase 7A variant 3 (HDAC7A) mRNA, complete cds. AK027781 - Homo sapiens cDNA FLJ14875 fis, clone PLACE1002816, weakly similar to HISTONE DEACETYLASE HDA1. JD439390 - Sequence 420414 from Patent EP1572962. JD544486 - Sequence 525510 from Patent EP1572962. JD426400 - Sequence 407424 from Patent EP1572962. JD218921 - Sequence 199945 from Patent EP1572962. JD077680 - Sequence 58704 from Patent EP1572962. JD115203 - Sequence 96227 from Patent EP1572962. JD320185 - Sequence 301209 from Patent EP1572962. JD259793 - Sequence 240817 from Patent EP1572962. JD391981 - Sequence 373005 from Patent EP1572962. JD401470 - Sequence 382494 from Patent EP1572962. JD414079 - Sequence 395103 from Patent EP1572962. JD243325 - Sequence 224349 from Patent EP1572962. JD043923 - Sequence 24947 from Patent EP1572962. JD485414 - Sequence 466438 from Patent EP1572962. JD564888 - Sequence 545912 from Patent EP1572962. JD159789 - Sequence 140813 from Patent EP1572962. JD137954 - Sequence 118978 from Patent EP1572962. JD076887 - Sequence 57911 from Patent EP1572962. JD314009 - Sequence 295033 from Patent EP1572962. JD426527 - Sequence 407551 from Patent EP1572962. AK303481 - Homo sapiens cDNA FLJ56194 complete cds, highly similar to Histone deacetylase 7a. AF239243 - Homo sapiens histone deacetylase 7 (HDAC7) mRNA, complete cds. AK301545 - Homo sapiens cDNA FLJ59774 complete cds, highly similar to Histone deacetylase 7a. JD473327 - Sequence 454351 from Patent EP1572962. AK299292 - Homo sapiens cDNA FLJ56143 complete cds, highly similar to Histone deacetylase 7a. AY302468 - Homo sapiens histone deacetylase (HDAC7) mRNA, complete cds. KJ902604 - Synthetic construct Homo sapiens clone ccsbBroadEn_11998 HDAC7 gene, encodes complete protein. BT009771 - Homo sapiens histone deacetylase 7A mRNA, complete cds. AB489177 - Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system. AK309547 - Homo sapiens cDNA, FLJ99588. JD270685 - Sequence 251709 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ranbp2Pathway - Sumoylation by RanBP2 Regulates Transcriptional Repression h_MITRPathway - Signal Dependent Regulation of Myogenesis by Corepressor MITR