Human Gene GEM (uc003ygj.3) Description and Page Index
Description: Homo sapiens GTP binding protein overexpressed in skeletal muscle (GEM), transcript variant 1, mRNA. RefSeq Summary (NM_005261): The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:95,261,485-95,274,547 Size: 13,063 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr8:95,262,538-95,272,731 Size: 10,194 Coding Exon Count: 4
ID:GEM_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein GEM; AltName: Full=GTP-binding mitogen-induced T-cell protein; AltName: Full=RAS-like protein KIR; FUNCTION: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. SUBUNIT: Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1. INTERACTION: P36406:TRIM23; NbExp=3; IntAct=EBI-744104, EBI-740098; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. TISSUE SPECIFICITY: Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle. INDUCTION: By mitogens. PTM: Phosphorylated on tyrosine residues. SIMILARITY: Belongs to the small GTPase superfamily. RGK family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55040
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.