Human Gene ESYT2 (uc003wob.1) Description and Page Index
  Description: Homo sapiens extended synaptotagmin-like protein 2 (ESYT2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:158,523,689-158,622,319 Size: 98,631 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr7:158,526,898-158,622,253 Size: 95,356 Coding Exon Count: 22 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:158,523,689-158,622,319)mRNA (may differ from genome)Protein (893 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.67 RPKM in Artery - Tibial
Total median expression: 957.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.1066-0.229 Picture PostScript Text
3' UTR -946.233209-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00168 - C2 domain
PF17047 - Synaptotagmin-like mitochondrial-lipid-binding domain

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)

ModBase Predicted Comparative 3D Structure on A0FGR8-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
   Gene DetailsGene Details 
   Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Descriptions from all associated GenBank mRNAs
  AL833233 - Homo sapiens mRNA; cDNA DKFZp762I0611 (from clone DKFZp762I0611).
AB033054 - Homo sapiens mRNA for KIAA1228 protein, partial cds.
AY368150 - Homo sapiens KIAA1228 protein mRNA, complete cds.
AK126214 - Homo sapiens cDNA FLJ44226 fis, clone THYMU3006172, moderately similar to Rattus norvegicus membrane bound C2 domain containing protein (Mbc2).
AK308824 - Homo sapiens cDNA, FLJ98865.
DQ993201 - Homo sapiens extended-synaptotagmin 2 (ESYT2) mRNA, complete cds.
BC152806 - Synthetic construct Homo sapiens clone IMAGE:100016092, MGC:184121 family with sequence similarity 62 (C2 domain containing) member B (FAM62B) mRNA, encodes complete protein.
AB527334 - Synthetic construct DNA, clone: pF1KE0066, Homo sapiens FAM62B gene for extended synaptotagmin-like protein 2, without stop codon, in Flexi system.
JD312941 - Sequence 293965 from Patent EP1572962.
AK056953 - Homo sapiens cDNA FLJ32391 fis, clone SKMUS1000186.
JD234282 - Sequence 215306 from Patent EP1572962.
JD208624 - Sequence 189648 from Patent EP1572962.
JD158775 - Sequence 139799 from Patent EP1572962.
JD127998 - Sequence 109022 from Patent EP1572962.
JD462380 - Sequence 443404 from Patent EP1572962.
JD076533 - Sequence 57557 from Patent EP1572962.
JD187599 - Sequence 168623 from Patent EP1572962.
JD326270 - Sequence 307294 from Patent EP1572962.
JD327835 - Sequence 308859 from Patent EP1572962.
JD082917 - Sequence 63941 from Patent EP1572962.
JD376425 - Sequence 357449 from Patent EP1572962.
JD460148 - Sequence 441172 from Patent EP1572962.
JD358442 - Sequence 339466 from Patent EP1572962.
JD076767 - Sequence 57791 from Patent EP1572962.
JD508522 - Sequence 489546 from Patent EP1572962.
JD486233 - Sequence 467257 from Patent EP1572962.
JD097055 - Sequence 78079 from Patent EP1572962.
JD053282 - Sequence 34306 from Patent EP1572962.
JD097072 - Sequence 78096 from Patent EP1572962.
JD226048 - Sequence 207072 from Patent EP1572962.
JD161763 - Sequence 142787 from Patent EP1572962.
JD196346 - Sequence 177370 from Patent EP1572962.
JD497996 - Sequence 479020 from Patent EP1572962.
JD222843 - Sequence 203867 from Patent EP1572962.
JD196346 - Sequence 177370 from Patent EP1572962.
JD161763 - Sequence 142787 from Patent EP1572962.
JD222843 - Sequence 203867 from Patent EP1572962.
JD147140 - Sequence 128164 from Patent EP1572962.
JD496128 - Sequence 477152 from Patent EP1572962.
JD136683 - Sequence 117707 from Patent EP1572962.
JD309760 - Sequence 290784 from Patent EP1572962.
JD059240 - Sequence 40264 from Patent EP1572962.
JD189911 - Sequence 170935 from Patent EP1572962.
JD273314 - Sequence 254338 from Patent EP1572962.
JD423077 - Sequence 404101 from Patent EP1572962.
JD295805 - Sequence 276829 from Patent EP1572962.
JD492968 - Sequence 473992 from Patent EP1572962.
AK001181 - Homo sapiens cDNA FLJ10319 fis, clone NT2RM2000490, weakly similar to SYNAPTOTAGMIN.
AK026710 - Homo sapiens cDNA: FLJ23057 fis, clone LNG03755.
BC013957 - Homo sapiens family with sequence similarity 62 (C2 domain containing) member B, mRNA (cDNA clone IMAGE:2959461), partial cds.
AK124091 - Homo sapiens cDNA FLJ42097 fis, clone TESOP2005285.
JD166104 - Sequence 147128 from Patent EP1572962.
JD225291 - Sequence 206315 from Patent EP1572962.
JD486527 - Sequence 467551 from Patent EP1572962.
JD125119 - Sequence 106143 from Patent EP1572962.
JD525123 - Sequence 506147 from Patent EP1572962.
JD528645 - Sequence 509669 from Patent EP1572962.
JD254432 - Sequence 235456 from Patent EP1572962.
JD227140 - Sequence 208164 from Patent EP1572962.
AJ303365 - Homo sapiens partial mRNA for FAM62B.
JD150523 - Sequence 131547 from Patent EP1572962.
JD406903 - Sequence 387927 from Patent EP1572962.
JD523469 - Sequence 504493 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein A0FGR8 (Reactome details) participates in the following event(s):

R-HSA-8857662 ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A0FGR8-2, FAM62B, KIAA1228, NM_020728, NP_065779
UCSC ID: uc003wob.1
RefSeq Accession: NM_020728
Protein: A0FGR8-2, splice isoform of A0FGR8 CCDS: CCDS34791.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020728.2
exon count: 22CDS single in 3' UTR: no RNA size: 5957
ORF size: 2682CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5564.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.