Human Gene TEAD3 (uc003oku.4) Description and Page Index
  Description: Homo sapiens TEA domain family member 3 (TEAD3), mRNA.
RefSeq Summary (NM_003214): This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF142482.1, BC091488.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 10379887 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr6:35,441,374-35,464,861 Size: 23,488 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr6:35,442,821-35,454,439 Size: 11,619 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:35,441,374-35,464,861)mRNA (may differ from genome)Protein (435 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transcriptional enhancer factor TEF-5; AltName: Full=DTEF-1; AltName: Full=TEA domain family member 3; Short=TEAD-3;
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
SUBUNIT: Interacts with YAP1 and WWTR1/TAZ.
TISSUE SPECIFICITY: Preferentially expressed in the placenta.
SIMILARITY: Contains 1 TEA DNA-binding domain.
SEQUENCE CAUTION: Sequence=AAH27877.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon; Sequence=AAH91488.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon; Sequence=CAA64213.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TEAD3
CDC HuGE Published Literature: TEAD3
Positive Disease Associations: Stroke
Related Studies:
  1. Stroke
    , , . [PubMed 0]
  2. Stroke
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 81.87 RPKM in Colon - Sigmoid
Total median expression: 1145.10 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.63236-0.392 Picture PostScript Text
3' UTR -623.541447-0.431 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000818 - TEA/ATTS
IPR016361 - TEF

Pfam Domains:
PF01285 - TEA/ATTS domain family

ModBase Predicted Comparative 3D Structure on Q99594
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007565 female pregnancy
GO:0035329 hippo signaling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048568 embryonic organ development
GO:0055059 asymmetric neuroblast division

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex

-  Descriptions from all associated GenBank mRNAs
  BC027877 - Homo sapiens TEA domain family member 3, mRNA (cDNA clone MGC:34093 IMAGE:5207501), complete cds.
AK226144 - Homo sapiens mRNA for TEA domain family member 3 variant, clone: pj02363.
BC010053 - Homo sapiens TEA domain family member 3, mRNA (cDNA clone IMAGE:3844747), partial cds.
BC091488 - Homo sapiens TEA domain family member 3, mRNA (cDNA clone MGC:111054 IMAGE:6187474), complete cds.
AF142482 - Homo sapiens transcription enhancer factor-5 mRNA, complete cds.
JD229138 - Sequence 210162 from Patent EP1572962.
JD147560 - Sequence 128584 from Patent EP1572962.
JD288312 - Sequence 269336 from Patent EP1572962.
JD051008 - Sequence 32032 from Patent EP1572962.
JD387191 - Sequence 368215 from Patent EP1572962.
JD096915 - Sequence 77939 from Patent EP1572962.
JD060674 - Sequence 41698 from Patent EP1572962.
JD499341 - Sequence 480365 from Patent EP1572962.
JD499340 - Sequence 480364 from Patent EP1572962.
JD488918 - Sequence 469942 from Patent EP1572962.
JD466692 - Sequence 447716 from Patent EP1572962.
JD522598 - Sequence 503622 from Patent EP1572962.
JD476078 - Sequence 457102 from Patent EP1572962.
JD493712 - Sequence 474736 from Patent EP1572962.
JD277855 - Sequence 258879 from Patent EP1572962.
JD377721 - Sequence 358745 from Patent EP1572962.
JD099043 - Sequence 80067 from Patent EP1572962.
JD149171 - Sequence 130195 from Patent EP1572962.
JD271946 - Sequence 252970 from Patent EP1572962.
JD246314 - Sequence 227338 from Patent EP1572962.
JD315392 - Sequence 296416 from Patent EP1572962.
JD504086 - Sequence 485110 from Patent EP1572962.
JD141134 - Sequence 122158 from Patent EP1572962.
JD189906 - Sequence 170930 from Patent EP1572962.
JD411530 - Sequence 392554 from Patent EP1572962.
JD147571 - Sequence 128595 from Patent EP1572962.
JD118117 - Sequence 99141 from Patent EP1572962.
JD249223 - Sequence 230247 from Patent EP1572962.
JD357740 - Sequence 338764 from Patent EP1572962.
JD373747 - Sequence 354771 from Patent EP1572962.
JD453508 - Sequence 434532 from Patent EP1572962.
JF432847 - Synthetic construct Homo sapiens clone IMAGE:100074168 TEA domain family member 3 (TEAD3) gene, encodes complete protein.
KJ904572 - Synthetic construct Homo sapiens clone ccsbBroadEn_13966 TEAD3 gene, encodes complete protein.
X94439 - Homo sapiens mRNA for TEF-5 protein.
JD209935 - Sequence 190959 from Patent EP1572962.
JD147570 - Sequence 128594 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99594 (Reactome details) participates in the following event(s):

R-HSA-8871266 YAP1 binds TEAD3
R-HSA-2032781 WWTR1 (TAZ) binds TEAD
R-HSA-8951695 TEADs:YAP1 binds CTGF gene
R-HSA-8951676 RUNX3 binds TEADs and YAP1
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_003214, NP_003205, O95910, Q5BJG7, Q8N6Y4, Q99594, TEAD3_HUMAN, TEAD5, TEF5
UCSC ID: uc003oku.4
RefSeq Accession: NM_003214
Protein: Q99594 (aka TEAD3_HUMAN or TEA3_HUMAN)
CCDS: CCDS47414.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003214.3
exon count: 13CDS single in 3' UTR: no RNA size: 3023
ORF size: 1308CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2186.00frame shift in genome: no % Coverage: 98.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.