Human Gene FKBP10 (uc002hxv.2) Description and Page Index
Description: Homo sapiens FK506 binding protein 10, 65 kDa (FKBP10), mRNA. RefSeq Summary (NM_021939): The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL832985.1, BC016467.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr17:39,968,962-39,979,469 Size: 10,508 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr17:39,969,287-39,978,660 Size: 9,374 Coding Exon Count: 10
ID:FKB10_HUMAN DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP10; Short=PPIase FKBP10; EC=18.104.22.168; AltName: Full=65 kDa FK506-binding protein; Short=65 kDa FKBP; Short=FKBP-65; AltName: Full=FK506-binding protein 10; Short=FKBP-10; AltName: Full=Immunophilin FKBP65; AltName: Full=Rotamase; Flags: Precursor; FUNCTION: PPIases accelerate the folding of proteins during protein synthesis. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). ENZYME REGULATION: Inhibited by both FK506 and rapamycin, but not by cyclosporin A (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity). PTM: Glycosylated and phosphorylated (By similarity). DISEASE: Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6) [MIM:610968]. OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass. SIMILARITY: Contains 2 EF-hand domains. SIMILARITY: Contains 4 PPIase FKBP-type domains. SEQUENCE CAUTION: Sequence=BAB15220.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=Osteogenesis imperfecta variant database; Note=Peptidyl-prolyl cis-trans isomerase FKBP10; URL="http://oi.gene.le.ac.uk/home.php?select_db=FKBP10";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AY3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.