Human Gene PRSS23 (uc001pcb.3) Description and Page Index
  Description: Homo sapiens protease, serine, 23 (PRSS23), mRNA.
RefSeq Summary (NM_007173): This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.135436.1, AK075362.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000280258.6/ ENSP00000280258.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr11:86,511,491-86,522,273 Size: 10,783 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr11:86,518,686-86,519,837 Size: 1,152 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:86,511,491-86,522,273)mRNA (may differ from genome)Protein (383 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDHuman Cortex Gene ExpressionLynx
MGIneXtProtOMIMPubMedReactomeStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serine protease 23; EC=3.4.21.-; AltName: Full=Putative secreted protein Zsig13; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the peptidase S1 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRSS23
CDC HuGE Published Literature: PRSS23

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D004997 Ethinyl Estradiol
  • D013749 Tetrachlorodibenzodioxin
  • C006253 pirinixic acid
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • D015124 8-Bromo Cyclic Adenosine Monophosphate
  • D016604 Aflatoxin B1
  • D017638 Asbestos, Crocidolite
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.71 RPKM in Artery - Aorta
Total median expression: 794.67 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.50216-0.650 Picture PostScript Text
3' UTR -621.412436-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6

Pfam Domains:
PF00089 - Trypsin
PF13365 - Trypsin-like peptidase domain

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on O95084
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process

Cellular Component:
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005788 endoplasmic reticulum lumen
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  LF207765 - JP 2014500723-A/15268: Polycomb-Associated Non-Coding RNAs.
BC063022 - Homo sapiens cDNA clone IMAGE:5246259, partial cds.
MA443342 - JP 2018138019-A/15268: Polycomb-Associated Non-Coding RNAs.
LF212127 - JP 2014500723-A/19630: Polycomb-Associated Non-Coding RNAs.
AK316508 - Homo sapiens cDNA, FLJ79407 complete cds, highly similar to Serine protease 23 precursor (EC 3.4.21.-).
AK315562 - Homo sapiens cDNA, FLJ96633, Homo sapiens protease, serine, 23 (SPUVE), mRNA.
AK075362 - Homo sapiens cDNA PSEC0048 fis, clone NT2RP2000028, highly similar to Serine protease 23 precursor (EC 3.4.21.-).
AK304301 - Homo sapiens cDNA FLJ51190 complete cds, highly similar to Serine protease 23 precursor (EC 3.4.21.-).
AK304054 - Homo sapiens cDNA FLJ52217 complete cds, highly similar to Serine protease 23 precursor (EC 3.4.21.-).
AL136914 - Homo sapiens mRNA; cDNA DKFZp586B0719 (from clone DKFZp586B0719).
BC001278 - Homo sapiens protease, serine, 23, mRNA (cDNA clone MGC:5107 IMAGE:3460054), complete cds.
AF015287 - Homo sapiens serine protease mRNA, complete cds.
AF193611 - Homo sapiens putative secreted protein ZSIG13 (ZSIG13) mRNA, complete cds.
AY359033 - Homo sapiens clone DNA41225 SPUVE (UNQ270) mRNA, complete cds.
JD404666 - Sequence 385690 from Patent EP1572962.
LF207767 - JP 2014500723-A/15270: Polycomb-Associated Non-Coding RNAs.
AB528215 - Synthetic construct DNA, clone: pF1KE0426, Homo sapiens PRSS23 gene for protease, serine, 23, without stop codon, in Flexi system.
CU674646 - Synthetic construct Homo sapiens gateway clone IMAGE:100017142 5' read PRSS23 mRNA.
KJ893225 - Synthetic construct Homo sapiens clone ccsbBroadEn_02619 PRSS23 gene, encodes complete protein.
AM392532 - Synthetic construct Homo sapiens clone IMAGE:100002086 for hypothetical protein (PRSS23 gene).
AM393531 - Synthetic construct Homo sapiens clone IMAGE:100002084 for hypothetical protein (PRSS23 gene).
CR456824 - Homo sapiens full open reading frame cDNA clone RZPDo834E0518D for gene SPUVE, protease, serine, 23; complete cds, incl. stopcodon.
LF368656 - JP 2014500723-A/176159: Polycomb-Associated Non-Coding RNAs.
LF368655 - JP 2014500723-A/176158: Polycomb-Associated Non-Coding RNAs.
LF368653 - JP 2014500723-A/176156: Polycomb-Associated Non-Coding RNAs.
LF368650 - JP 2014500723-A/176153: Polycomb-Associated Non-Coding RNAs.
LF368648 - JP 2014500723-A/176151: Polycomb-Associated Non-Coding RNAs.
JD240164 - Sequence 221188 from Patent EP1572962.
JD242101 - Sequence 223125 from Patent EP1572962.
LF368647 - JP 2014500723-A/176150: Polycomb-Associated Non-Coding RNAs.
JD344386 - Sequence 325410 from Patent EP1572962.
LF368646 - JP 2014500723-A/176149: Polycomb-Associated Non-Coding RNAs.
LF368645 - JP 2014500723-A/176148: Polycomb-Associated Non-Coding RNAs.
MA604233 - JP 2018138019-A/176159: Polycomb-Associated Non-Coding RNAs.
MA604232 - JP 2018138019-A/176158: Polycomb-Associated Non-Coding RNAs.
MA604230 - JP 2018138019-A/176156: Polycomb-Associated Non-Coding RNAs.
MA604227 - JP 2018138019-A/176153: Polycomb-Associated Non-Coding RNAs.
MA604225 - JP 2018138019-A/176151: Polycomb-Associated Non-Coding RNAs.
MA604224 - JP 2018138019-A/176150: Polycomb-Associated Non-Coding RNAs.
MA604223 - JP 2018138019-A/176149: Polycomb-Associated Non-Coding RNAs.
MA604222 - JP 2018138019-A/176148: Polycomb-Associated Non-Coding RNAs.
MA447704 - JP 2018138019-A/19630: Polycomb-Associated Non-Coding RNAs.
MA443344 - JP 2018138019-A/15270: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95084 (Reactome details) participates in the following event(s):

R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDJ1, NM_007173, NP_009104, O95084, PRS23_HUMAN, Q6IBI0, UNQ270/PRO307, ZSIG13
UCSC ID: uc001pcb.3
RefSeq Accession: NM_007173
Protein: O95084 (aka PRS23_HUMAN or PS23_HUMAN)
CCDS: CCDS8278.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_007173.4
exon count: 2CDS single in 3' UTR: no RNA size: 3806
ORF size: 1152CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2462.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 3444# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.