Human Gene RSU1 (uc001iol.3) Description and Page Index
  Description: Homo sapiens Ras suppressor protein 1 (RSU1), transcript variant 1, mRNA.
RefSeq Summary (NM_012425): This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr10:16,632,617-16,859,453 Size: 226,837 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr10:16,635,393-16,859,080 Size: 223,688 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:16,632,617-16,859,453)mRNA (may differ from genome)Protein (277 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ras suppressor protein 1; Short=RSP-1; Short=Rsu-1;
FUNCTION: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.
SIMILARITY: Contains 7 LRR (leucine-rich) repeats.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RSU1
CDC HuGE Published Literature: RSU1
Positive Disease Associations: Stroke
Related Studies:
  1. Stroke
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.59 RPKM in Artery - Tibial
Total median expression: 806.59 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.60143-0.368 Picture PostScript Text
3' UTR -745.462776-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies
IPR003591 - Leu-rich_rpt_typical-subtyp

Pfam Domains:
PF12799 - Leucine Rich repeats (2 copies)
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q15404
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0010811 positive regulation of cell-substrate adhesion
GO:0043547 positive regulation of GTPase activity
GO:0010810 regulation of cell-substrate adhesion

Cellular Component:
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  BX647733 - Homo sapiens mRNA; cDNA DKFZp686J03262 (from clone DKFZp686J03262).
L12535 - Human RSU-1/RSP-1 mRNA, complete cds.
BC005993 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone MGC:14796 IMAGE:4050837), complete cds.
BC107898 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone IMAGE:30320269), partial cds.
BC015644 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone MGC:23361 IMAGE:4647836), complete cds.
BC008691 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone MGC:8886 IMAGE:3872071), complete cds.
AK292911 - Homo sapiens cDNA FLJ77304 complete cds, highly similar to Homo sapiens Ras suppressor protein 1 (RSU1), transcript variant 2, mRNA.
CR536521 - Homo sapiens full open reading frame cDNA clone RZPDo834D1120D for gene RSU1, Ras suppressor protein 1; complete cds, incl. stopcodon.
AK312520 - Homo sapiens cDNA, FLJ92885, Homo sapiens Ras suppressor protein 1 (RSU1), mRNA.
CU679047 - Synthetic construct Homo sapiens gateway clone IMAGE:100016954 5' read RSU1 mRNA.
KJ892075 - Synthetic construct Homo sapiens clone ccsbBroadEn_01469 RSU1 gene, encodes complete protein.
CR541840 - Homo sapiens full open reading frame cDNA clone RZPDo834B1032D for gene RSU1, Ras suppressor protein 1; complete cds, without stopcodon.
AB590762 - Synthetic construct DNA, clone: pFN21AE1771, Homo sapiens RSU1 gene for Ras suppressor protein 1, without stop codon, in Flexi system.
BC016337 - Homo sapiens Ras suppressor protein 1, mRNA (cDNA clone IMAGE:4102897), with apparent retained intron.
AK055596 - Homo sapiens cDNA FLJ31034 fis, clone HSYRA1000178.
BC065296 - Homo sapiens cDNA clone IMAGE:6139254, partial cds.
JD509748 - Sequence 490772 from Patent EP1572962.
JD517665 - Sequence 498689 from Patent EP1572962.
JD091286 - Sequence 72310 from Patent EP1572962.
JD183278 - Sequence 164302 from Patent EP1572962.
JD333525 - Sequence 314549 from Patent EP1572962.
JD176321 - Sequence 157345 from Patent EP1572962.
JD055179 - Sequence 36203 from Patent EP1572962.
JD306307 - Sequence 287331 from Patent EP1572962.
JD074703 - Sequence 55727 from Patent EP1572962.
JD178983 - Sequence 160007 from Patent EP1572962.
JD169646 - Sequence 150670 from Patent EP1572962.
JD529391 - Sequence 510415 from Patent EP1572962.
JD091698 - Sequence 72722 from Patent EP1572962.
JD421515 - Sequence 402539 from Patent EP1572962.
JD294140 - Sequence 275164 from Patent EP1572962.
JD514948 - Sequence 495972 from Patent EP1572962.
JD423519 - Sequence 404543 from Patent EP1572962.
JD046021 - Sequence 27045 from Patent EP1572962.
JD362357 - Sequence 343381 from Patent EP1572962.
JD498111 - Sequence 479135 from Patent EP1572962.
JD343988 - Sequence 325012 from Patent EP1572962.
JD249897 - Sequence 230921 from Patent EP1572962.
JD148333 - Sequence 129357 from Patent EP1572962.
JD463845 - Sequence 444869 from Patent EP1572962.
JD478596 - Sequence 459620 from Patent EP1572962.
JD543284 - Sequence 524308 from Patent EP1572962.
JD249896 - Sequence 230920 from Patent EP1572962.
JD501099 - Sequence 482123 from Patent EP1572962.
JD492795 - Sequence 473819 from Patent EP1572962.
JD328092 - Sequence 309116 from Patent EP1572962.
JD102360 - Sequence 83384 from Patent EP1572962.
JD302452 - Sequence 283476 from Patent EP1572962.
JD504649 - Sequence 485673 from Patent EP1572962.
JD556649 - Sequence 537673 from Patent EP1572962.
JD048262 - Sequence 29286 from Patent EP1572962.
JD049190 - Sequence 30214 from Patent EP1572962.
JD303262 - Sequence 284286 from Patent EP1572962.
JD385669 - Sequence 366693 from Patent EP1572962.
JD551758 - Sequence 532782 from Patent EP1572962.
JD325668 - Sequence 306692 from Patent EP1572962.
JD317084 - Sequence 298108 from Patent EP1572962.
JD275096 - Sequence 256120 from Patent EP1572962.
JD391015 - Sequence 372039 from Patent EP1572962.
AK225681 - Homo sapiens mRNA for ras suppressor protein 1 isoform 1 variant, clone: SYN02524.
AK023951 - Homo sapiens cDNA FLJ13889 fis, clone THYRO1001595.
JD396720 - Sequence 377744 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15404 (Reactome details) participates in the following event(s):

R-HSA-430311 Rsu-1 interacts with Pinch1
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446728 Cell junction organization
R-HSA-1500931 Cell-Cell communication

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA46, D3DRU3, NM_012425, NP_689937, Q15404, Q6FI17, RSP1, RSU1_HUMAN
UCSC ID: uc001iol.3
RefSeq Accession: NM_012425
Protein: Q15404 (aka RSU1_HUMAN)
CCDS: CCDS7112.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_012425.3
exon count: 9CDS single in 3' UTR: no RNA size: 3769
ORF size: 834CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1759.00frame shift in genome: no % Coverage: 99.58
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.