Human Gene RSU1 (uc001iol.3) Description and Page Index
Description: Homo sapiens Ras suppressor protein 1 (RSU1), transcript variant 1, mRNA. RefSeq Summary (NM_012425): This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr10:16,632,617-16,859,453 Size: 226,837 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr10:16,635,393-16,859,080 Size: 223,688 Coding Exon Count: 8
ID:RSU1_HUMAN DESCRIPTION: RecName: Full=Ras suppressor protein 1; Short=RSP-1; Short=Rsu-1; FUNCTION: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. SIMILARITY: Contains 7 LRR (leucine-rich) repeats.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RSU1 CDC HuGE Published Literature: RSU1 Positive Disease Associations: Stroke Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on Q15404
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.