Human Gene PHF14 (uc003sry.2) Description and Page Index
  Description: Homo sapiens PHD finger protein 14 (PHF14), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:11,013,499-11,147,376 Size: 133,878 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr7:11,013,951-11,142,125 Size: 128,175 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:11,013,499-11,147,376)mRNA (may differ from genome)Protein (888 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIneXtProt
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: PHF14_HUMAN
DESCRIPTION: RecName: Full=PHD finger protein 14;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SIMILARITY: Contains 2 PHD-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAA34503.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.85 RPKM in Ovary
Total median expression: 211.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -197.14452-0.436 Picture PostScript Text
3' UTR -1196.605251-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019786 - Zinc_finger_PHD-type_CS
IPR011011 - Znf_FYVE_PHD
IPR001965 - Znf_PHD
IPR019787 - Znf_PHD-finger
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00628 - PHD-finger
PF13771 - PHD-like zinc-binding domain
PF13832 - PHD-zinc-finger like domain

SCOP Domains:
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on O94880
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0048286 lung alveolus development
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000791 negative regulation of mesenchymal cell proliferation involved in lung development

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK294419 - Homo sapiens cDNA FLJ61230 complete cds, highly similar to PHD finger protein 14.
AK295461 - Homo sapiens cDNA FLJ57112 complete cds, highly similar to PHD finger protein 14.
AB018326 - Homo sapiens KIAA0783 mRNA for KIAA0783 protein.
BC152414 - Homo sapiens PHD finger protein 14, mRNA (cDNA clone MGC:176640 IMAGE:8862519), complete cds.
JD262771 - Sequence 243795 from Patent EP1572962.
JD141761 - Sequence 122785 from Patent EP1572962.
JD464890 - Sequence 445914 from Patent EP1572962.
JD256687 - Sequence 237711 from Patent EP1572962.
AB463167 - Synthetic construct DNA, clone: pF1KA0783, Homo sapiens PHF14 gene for PHD finger protein 14, without stop codon, in Flexi system.
KJ898070 - Synthetic construct Homo sapiens clone ccsbBroadEn_07464 PHF14 gene, encodes complete protein.
LF342698 - JP 2014500723-A/150201: Polycomb-Associated Non-Coding RNAs.
LF342699 - JP 2014500723-A/150202: Polycomb-Associated Non-Coding RNAs.
BC104657 - Homo sapiens cDNA clone IMAGE:4248289.
LF342700 - JP 2014500723-A/150203: Polycomb-Associated Non-Coding RNAs.
LF342701 - JP 2014500723-A/150204: Polycomb-Associated Non-Coding RNAs.
MA578275 - JP 2018138019-A/150201: Polycomb-Associated Non-Coding RNAs.
MA578276 - JP 2018138019-A/150202: Polycomb-Associated Non-Coding RNAs.
MA578277 - JP 2018138019-A/150203: Polycomb-Associated Non-Coding RNAs.
MA578278 - JP 2018138019-A/150204: Polycomb-Associated Non-Coding RNAs.
JD115051 - Sequence 96075 from Patent EP1572962.
JD509209 - Sequence 490233 from Patent EP1572962.
JD082770 - Sequence 63794 from Patent EP1572962.
JD314312 - Sequence 295336 from Patent EP1572962.
JD237702 - Sequence 218726 from Patent EP1572962.
JD147277 - Sequence 128301 from Patent EP1572962.
JD552646 - Sequence 533670 from Patent EP1572962.
JD553436 - Sequence 534460 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A7MCZ3, B4DI82, KIAA0783, NM_014660, NP_055475, O94880, PHF14_HUMAN
UCSC ID: uc003sry.2
RefSeq Accession: NM_014660
Protein: O94880 (aka PHF14_HUMAN or PHFE_HUMAN)
CCDS: CCDS47542.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014660.3
exon count: 17CDS single in 3' UTR: no RNA size: 8370
ORF size: 2667CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5531.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.