Human Gene SLC7A6OS (uc002evw.2) Description and Page Index
  Description: Homo sapiens solute carrier family 7, member 6 opposite strand (SLC7A6OS), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:68,334,518-68,344,868 Size: 10,351 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr16:68,335,178-68,344,829 Size: 9,652 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:68,334,518-68,344,868)mRNA (may differ from genome)Protein (309 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Probable RNA polymerase II nuclear localization protein SLC7A6OS; AltName: Full=ADAMS proteinase-related protein; AltName: Full=Solute carrier family 7 member 6 opposite strand transcript;
FUNCTION: Directs RNA polymerase II nuclear import (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
MISCELLANEOUS: When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells (PubMed:21504834).
SIMILARITY: Belongs to the IWR1/SLC7A6OS family.
SEQUENCE CAUTION: Sequence=AAL79958.1; Type=Frameshift; Positions=234;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.41 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 177.41 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.0039-0.308 Picture PostScript Text
3' UTR -195.30660-0.296 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF08574 - Transcription factor Iwr1

ModBase Predicted Comparative 3D Structure on Q96CW6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0002244 hematopoietic progenitor cell differentiation
GO:0015031 protein transport

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AK091674 - Homo sapiens cDNA FLJ34355 fis, clone FEBRA2012181.
BC013778 - Homo sapiens solute carrier family 7, member 6 opposite strand, mRNA (cDNA clone MGC:16850 IMAGE:4345035), complete cds.
AK225712 - Homo sapiens mRNA for hypothetical protein LOC84138 variant, clone: TMS08305.
LF384441 - JP 2014500723-A/191944: Polycomb-Associated Non-Coding RNAs.
AK023353 - Homo sapiens cDNA FLJ13291 fis, clone OVARC1001176.
JD328582 - Sequence 309606 from Patent EP1572962.
AY078070 - Homo sapiens proteinase-related protein mRNA, complete cds.
JD462412 - Sequence 443436 from Patent EP1572962.
JD183014 - Sequence 164038 from Patent EP1572962.
LF374229 - JP 2014500723-A/181732: Polycomb-Associated Non-Coding RNAs.
LF374230 - JP 2014500723-A/181733: Polycomb-Associated Non-Coding RNAs.
LF374231 - JP 2014500723-A/181734: Polycomb-Associated Non-Coding RNAs.
MA620018 - JP 2018138019-A/191944: Polycomb-Associated Non-Coding RNAs.
MA609806 - JP 2018138019-A/181732: Polycomb-Associated Non-Coding RNAs.
MA609807 - JP 2018138019-A/181733: Polycomb-Associated Non-Coding RNAs.
MA609808 - JP 2018138019-A/181734: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_032178, NP_115554, Q8TCZ3, Q96CW6, Q9H8R8, S7A6O_HUMAN
UCSC ID: uc002evw.2
RefSeq Accession: NM_032178
Protein: Q96CW6 (aka S7A6O_HUMAN)
CCDS: CCDS10865.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032178.2
exon count: 5CDS single in 3' UTR: no RNA size: 1642
ORF size: 930CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1589.00frame shift in genome: no % Coverage: 99.21
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.