Human Gene HAUS2 (uc001zqe.3) Description and Page Index
Description: Homo sapiens HAUS augmin-like complex, subunit 2 (HAUS2), transcript variant 1, mRNA. RefSeq Summary (NM_018097): The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]. Transcript (Including UTRs) Position: hg19 chr15:42,841,011-42,862,190 Size: 21,180 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr15:42,841,071-42,859,014 Size: 17,944 Coding Exon Count: 6
ID:HAUS2_HUMAN DESCRIPTION: RecName: Full=HAUS augmin-like complex subunit 2; AltName: Full=Centrosomal protein of 27 kDa; FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. SUBUNIT: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. SIMILARITY: Belongs to the HAUS2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF15003 - HAUS augmin-like complex subunit 2
ModBase Predicted Comparative 3D Structure on Q9NVX0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.