Human Gene HAUS2 (uc001zqe.3) Description and Page Index
  Description: Homo sapiens HAUS augmin-like complex, subunit 2 (HAUS2), transcript variant 1, mRNA.
RefSeq Summary (NM_018097): The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016].
Transcript (Including UTRs)
   Position: hg19 chr15:42,841,011-42,862,190 Size: 21,180 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr15:42,841,071-42,859,014 Size: 17,944 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:42,841,011-42,862,190)mRNA (may differ from genome)Protein (235 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: HAUS2_HUMAN
DESCRIPTION: RecName: Full=HAUS augmin-like complex subunit 2; AltName: Full=Centrosomal protein of 27 kDa;
FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
SUBUNIT: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
SIMILARITY: Belongs to the HAUS2 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: HAUS2
Diseases sorted by gene-association score: joubert syndrome 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.27 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 195.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.5060-0.342 Picture PostScript Text
3' UTR -1133.313176-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026242 - HAUS2

Pfam Domains:
PF15003 - HAUS augmin-like complex subunit 2

ModBase Predicted Comparative 3D Structure on Q9NVX0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007049 cell cycle
GO:0007098 centrosome cycle
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0031023 microtubule organizing center organization
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0097711 ciliary basal body docking

Cellular Component:
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0070652 HAUS complex


-  Descriptions from all associated GenBank mRNAs
  AK022939 - Homo sapiens cDNA FLJ12877 fis, clone NT2RP2003825.
JD247712 - Sequence 228736 from Patent EP1572962.
BC010903 - Homo sapiens centrosomal protein 27kDa, mRNA (cDNA clone MGC:13414 IMAGE:4285311), complete cds.
AK001322 - Homo sapiens cDNA FLJ10460 fis, clone NT2RP1001475.
KJ899081 - Synthetic construct Homo sapiens clone ccsbBroadEn_08475 HAUS2 gene, encodes complete protein.
JD510780 - Sequence 491804 from Patent EP1572962.
JD412805 - Sequence 393829 from Patent EP1572962.
JD512778 - Sequence 493802 from Patent EP1572962.
JD426465 - Sequence 407489 from Patent EP1572962.
JD243282 - Sequence 224306 from Patent EP1572962.
JD358205 - Sequence 339229 from Patent EP1572962.
JD310423 - Sequence 291447 from Patent EP1572962.
JD195057 - Sequence 176081 from Patent EP1572962.
JD250198 - Sequence 231222 from Patent EP1572962.
JD089676 - Sequence 70700 from Patent EP1572962.
JD180516 - Sequence 161540 from Patent EP1572962.
JD267345 - Sequence 248369 from Patent EP1572962.
JD182656 - Sequence 163680 from Patent EP1572962.
JD084192 - Sequence 65216 from Patent EP1572962.
JD084193 - Sequence 65217 from Patent EP1572962.
JD246705 - Sequence 227729 from Patent EP1572962.
JD100433 - Sequence 81457 from Patent EP1572962.
JD405296 - Sequence 386320 from Patent EP1572962.
JD538039 - Sequence 519063 from Patent EP1572962.
JD140278 - Sequence 121302 from Patent EP1572962.
JD134980 - Sequence 116004 from Patent EP1572962.
JD102029 - Sequence 83053 from Patent EP1572962.
JD432447 - Sequence 413471 from Patent EP1572962.
JD277289 - Sequence 258313 from Patent EP1572962.
JD105600 - Sequence 86624 from Patent EP1572962.
JD158822 - Sequence 139846 from Patent EP1572962.
JD275677 - Sequence 256701 from Patent EP1572962.
JD111731 - Sequence 92755 from Patent EP1572962.
JD417460 - Sequence 398484 from Patent EP1572962.
JD258188 - Sequence 239212 from Patent EP1572962.
JD258425 - Sequence 239449 from Patent EP1572962.
JD258424 - Sequence 239448 from Patent EP1572962.
JD411899 - Sequence 392923 from Patent EP1572962.
JD411898 - Sequence 392922 from Patent EP1572962.
JD127574 - Sequence 108598 from Patent EP1572962.
JD341068 - Sequence 322092 from Patent EP1572962.
JD235903 - Sequence 216927 from Patent EP1572962.
JD564478 - Sequence 545502 from Patent EP1572962.
JD558372 - Sequence 539396 from Patent EP1572962.
JD319673 - Sequence 300697 from Patent EP1572962.
JD319674 - Sequence 300698 from Patent EP1572962.
JD106198 - Sequence 87222 from Patent EP1572962.
JD071439 - Sequence 52463 from Patent EP1572962.
JD430711 - Sequence 411735 from Patent EP1572962.
JD557858 - Sequence 538882 from Patent EP1572962.
JD531173 - Sequence 512197 from Patent EP1572962.
JD395634 - Sequence 376658 from Patent EP1572962.
JD112499 - Sequence 93523 from Patent EP1572962.
JD472378 - Sequence 453402 from Patent EP1572962.
JD199433 - Sequence 180457 from Patent EP1572962.
JD186057 - Sequence 167081 from Patent EP1572962.
JD066341 - Sequence 47365 from Patent EP1572962.
JD066342 - Sequence 47366 from Patent EP1572962.
JD308966 - Sequence 289990 from Patent EP1572962.
JD332492 - Sequence 313516 from Patent EP1572962.
JD448523 - Sequence 429547 from Patent EP1572962.
JD352105 - Sequence 333129 from Patent EP1572962.
JD257743 - Sequence 238767 from Patent EP1572962.
JD144116 - Sequence 125140 from Patent EP1572962.
JD230627 - Sequence 211651 from Patent EP1572962.
JD536871 - Sequence 517895 from Patent EP1572962.
JD155764 - Sequence 136788 from Patent EP1572962.
JD366129 - Sequence 347153 from Patent EP1572962.
JD250965 - Sequence 231989 from Patent EP1572962.
JD250966 - Sequence 231990 from Patent EP1572962.
JD508473 - Sequence 489497 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NVX0 (Reactome details) participates in the following event(s):

R-HSA-380272 Plk1-mediated phosphorylation of Nlp
R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380294 Loss of C-Nap-1 from centrosomes
R-HSA-380311 Recruitment of Plk1 to centrosomes
R-HSA-380455 Recruitment of CDK11p58 to the centrosomes
R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome
R-HSA-5626220 C2CD3 binds the mother centriole
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-2574845 AJUBA binds centrosome-associated AURKA
R-HSA-8853405 TPX2 binds AURKA at centrosomes
R-HSA-3000319 BORA binds PLK1 and AURKA
R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation
R-HSA-3000310 AURKA phosphorylates PLK1
R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
R-HSA-5626681 Recruitment of transition zone proteins
R-HSA-5626227 CP110 and CEP97 dissociate from the centriole
R-HSA-380316 Association of NuMA with microtubules
R-HSA-8853419 TPX2 promotes AURKA autophosphorylation
R-HSA-5626228 The distal appendage proteins recruit TTBK2
R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
R-HSA-5626699 MARK4 binds ODF2 in the centriole
R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-380287 Centrosome maturation
R-HSA-5617833 Cilium Assembly
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: C15orf25, C9JH36, CEP27, HAUS2_HUMAN, NM_018097, NP_060567, Q9H9B3, Q9NVX0
UCSC ID: uc001zqe.3
RefSeq Accession: NM_018097
Protein: Q9NVX0 (aka HAUS2_HUMAN)
CCDS: CCDS10090.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_018097.2
exon count: 6CDS single in 3' UTR: no RNA size: 3953
ORF size: 708CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1616.00frame shift in genome: no % Coverage: 99.77
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.