Human Gene ZZZ3 (uc001dhq.3) Description and Page Index
  Description: Homo sapiens zinc finger, ZZ-type containing 3 (ZZZ3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:78,030,190-78,148,343 Size: 118,154 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr1:78,031,325-78,099,039 Size: 67,715 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:78,030,190-78,148,343)mRNA (may differ from genome)Protein (903 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZZZ3_HUMAN
DESCRIPTION: RecName: Full=ZZ-type zinc finger-containing protein 3;
FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
SUBUNIT: Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.
SUBCELLULAR LOCATION: Nucleus (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 1 HTH myb-type DNA-binding domain.
SIMILARITY: Contains 1 ZZ-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.52 RPKM in Cells - Transformed fibroblasts
Total median expression: 198.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.30476-0.274 Picture PostScript Text
3' UTR -291.691135-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR017930 - Myb_dom
IPR001005 - SANT/Myb
IPR000433 - Znf_ZZ

Pfam Domains:
PF00249 - Myb-like DNA-binding domain
PF00569 - Zinc finger, ZZ type

SCOP Domains:
46689 - Homeodomain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2FC7
- NMR MuPIT

2YUM
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q8IYH5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
      
      
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  BX641096 - Homo sapiens mRNA; cDNA DKFZp686N03151 (from clone DKFZp686N03151).
BX641001 - Homo sapiens mRNA; cDNA DKFZp686C16148 (from clone DKFZp686C16148); complete cds.
BC035079 - Homo sapiens zinc finger, ZZ-type containing 3, mRNA (cDNA clone IMAGE:5260515), complete cds.
AK310514 - Homo sapiens cDNA, FLJ17556.
BX640658 - Homo sapiens mRNA; cDNA DKFZp313N0119 (from clone DKFZp313N0119).
AL080063 - Homo sapiens mRNA; cDNA DKFZp564I052 (from clone DKFZp564I052).
BC035397 - Homo sapiens zinc finger, ZZ-type containing 3, mRNA (cDNA clone IMAGE:5000886), partial cds.
BX640766 - Homo sapiens mRNA; cDNA DKFZp686C19210 (from clone DKFZp686C19210).
BC035818 - Homo sapiens zinc finger, ZZ-type containing 3, mRNA (cDNA clone MGC:46330 IMAGE:5554765), complete cds.
AK001224 - Homo sapiens cDNA FLJ10362 fis, clone NT2RM2001306, highly similar to Homo sapiens mRNA; cDNA DKFZp564I052.
AK074119 - Homo sapiens mRNA for FLJ00191 protein.
JD500099 - Sequence 481123 from Patent EP1572962.
JD305571 - Sequence 286595 from Patent EP1572962.
JD452472 - Sequence 433496 from Patent EP1572962.
JD375544 - Sequence 356568 from Patent EP1572962.
JD305971 - Sequence 286995 from Patent EP1572962.
JD236037 - Sequence 217061 from Patent EP1572962.
JD328341 - Sequence 309365 from Patent EP1572962.
JD307390 - Sequence 288414 from Patent EP1572962.
JD299777 - Sequence 280801 from Patent EP1572962.
JD359719 - Sequence 340743 from Patent EP1572962.
JD549672 - Sequence 530696 from Patent EP1572962.
JD258951 - Sequence 239975 from Patent EP1572962.
JD048532 - Sequence 29556 from Patent EP1572962.
JF432477 - Synthetic construct Homo sapiens clone IMAGE:100073698 zinc finger, ZZ-type containing 3 (ZZZ3) gene, encodes complete protein.
JF432513 - Synthetic construct Homo sapiens clone IMAGE:100073735 zinc finger, ZZ-type containing 3 (ZZZ3) gene, encodes complete protein.
KJ904708 - Synthetic construct Homo sapiens clone ccsbBroadEn_14102 ZZZ3 gene, encodes complete protein.
AB590541 - Synthetic construct DNA, clone: pFN21AE1288, Homo sapiens ZZZ3 gene for zinc finger, ZZ-type containing 3, without stop codon, in Flexi system.
JD326402 - Sequence 307426 from Patent EP1572962.
JD045490 - Sequence 26514 from Patent EP1572962.
BX649026 - Homo sapiens mRNA; cDNA DKFZp686I0598 (from clone DKFZp686I0598).

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IYH5 (Reactome details) participates in the following event(s):

R-HSA-3301237 KAT2 complexes acetylate histone H3
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: B7WPC6, NM_015534, NP_056349, Q6N004, Q6N070, Q8IYH5, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0, ZZZ3_HUMAN
UCSC ID: uc001dhq.3
RefSeq Accession: NM_015534
Protein: Q8IYH5 (aka ZZZ3_HUMAN)
CCDS: CCDS677.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015534.4
exon count: 15CDS single in 3' UTR: no RNA size: 4344
ORF size: 2712CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4709.00frame shift in genome: no % Coverage: 99.52
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.