Human Gene IKBKG (uc022cij.1) Description and Page Index
  Description: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:153,868,252-153,871,017 Size: 2,766 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chrX:153,868,254-153,869,899 Size: 1,646 Coding Exon Count: 4 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:153,868,252-153,871,017)mRNA (may differ from genome)Protein (162 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IKBKG
CDC HuGE Published Literature: IKBKG

-  MalaCards Disease Associations
  MalaCards Gene Search: IKBKG
Diseases sorted by gene-association score: incontinentia pigmenti* (1734), immunodeficiency 33* (1578), ectodermal dysplasia, hypohidrotic, with immune deficiency* (1300), immunodeficiency, isolated* (1300), ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency* (1250), invasive pneumococcal disease, recurrent isolated, 2* (1200), hypomelanosis of ito* (416), nf-kappa b essential modulator deficiency* (400), hypohidrotic ectodermal dysplasia with immunodeficiency* (247), familial atypical mycobacteriosis, x-linked, ikbkg-related* (100), ectodermal dysplasia (42), ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive (14), osteopetrosis (12), anhidrosis (11), subdural empyema (11), echolalia (10), tactile agnosia (9), lymphedema (8), dowling-degos disease 1 (7), immunodeficiency with hyper-igm, type 2 (4), venous malformations, multiple cutaneous and mucosal (4), popliteal pterygium syndrome 1 (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.3593-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF16516 - Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

ModBase Predicted Comparative 3D Structure on D3DWY2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016301 kinase activity
GO:0070530 K63-linked polyubiquitin binding

Biological Process:
GO:0016310 phosphorylation

-  Descriptions from all associated GenBank mRNAs
  JD239278 - Sequence 220302 from Patent EP1572962.
LF380938 - JP 2014500723-A/188441: Polycomb-Associated Non-Coding RNAs.
LF380937 - JP 2014500723-A/188440: Polycomb-Associated Non-Coding RNAs.
LF380936 - JP 2014500723-A/188439: Polycomb-Associated Non-Coding RNAs.
MA616515 - JP 2018138019-A/188441: Polycomb-Associated Non-Coding RNAs.
MA616514 - JP 2018138019-A/188440: Polycomb-Associated Non-Coding RNAs.
MA616513 - JP 2018138019-A/188439: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_tnfr2Pathway - TNFR2 Signaling Pathway
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_nfkbPathway - NF-kB Signaling Pathway
h_stressPathway - TNF/Stress Related Signaling
h_aktPathway - AKT Signaling Pathway
h_cd40Pathway - CD40L Signaling Pathway
h_tollPathway - Toll-Like Receptor Pathway
h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus

-  Other Names for This Gene
  Alternate Gene Symbols: CU674143, D3DWY2, D3DWY2_HUMAN, hCG_2003089, NM_003639, NP_003630
UCSC ID: uc022cij.1
Representative RNA: CU674143
Protein: D3DWY2

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene IKBKG:
i-p (Incontinentia Pigmenti)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: CU674143.1
exon count: 5CDS single in 3' UTR: no RNA size: 1303
ORF size: 486CDS single in intron: no Alignment % ID: 99.48
txCdsPredict score: 1122.00frame shift in genome: no % Coverage: 44.51
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.