Human Gene OR2V2 (uc011dhj.2) Description and Page Index
  Description: Homo sapiens olfactory receptor, family 2, subfamily V, member 2 (OR2V2), mRNA.
RefSeq Summary (NM_206880): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr5:180,581,943-180,582,890 Size: 948 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr5:180,581,943-180,582,890 Size: 948 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsGene AllelesRNA-Seq Expression
Microarray ExpressionProtein StructureOther SpeciesGO AnnotationsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:180,581,943-180,582,890)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: OR2V2_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 2V2; AltName: Full=Olfactory receptor 2V3; AltName: Full=Olfactory receptor OR5-3;
FUNCTION: Odorant receptor (Potential).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2V2";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OR2V2
CDC HuGE Published Literature: OR2V2
Positive Disease Associations: Basophils
Related Studies:
  1. Basophils
    , , . [PubMed 0]

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.05 RPKM in Testis
Total median expression: 0.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q96R30
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04740 - Olfactory transduction

Reactome (by CSHL, EBI, and GO)

Protein Q96R30 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_206880, NP_996763, OR2V2_HUMAN, OR2V3, Q6IFL6, Q8NGV1, Q96R30
UCSC ID: uc011dhj.2
RefSeq Accession: NM_206880
Protein: Q96R30 (aka OR2V2_HUMAN or O2V2_HUMAN)
CCDS: CCDS4461.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_206880.1
exon count: 1CDS single in 3' UTR: no RNA size: 948
ORF size: 948CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2090.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.