Human Gene OR10H5 (uc010xos.2) Description and Page Index
  Description: Homo sapiens olfactory receptor, family 10, subfamily H, member 5 (OR10H5), mRNA.
RefSeq Summary (NM_001004466): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr19:15,904,859-15,905,806 Size: 948 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr19:15,904,859-15,905,806 Size: 948 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsGene AllelesRNA-Seq Expression
Microarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:15,904,859-15,905,806)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: O10H5_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 10H5; AltName: Full=Olfactory receptor OR19-25; AltName: Full=Olfactory receptor OR19-26;
FUNCTION: Odorant receptor (Potential).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR10H5";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OR10H5
CDC HuGE Published Literature: OR10H5
Positive Disease Associations: Heart Rate
Related Studies:
  1. Heart Rate
    , , . [PubMed 0]

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.06 RPKM in Testis
Total median expression: 0.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q8NGA6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity
GO:0004993 G-protein coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC136869 - Homo sapiens olfactory receptor, family 10, subfamily H, member 5, mRNA (cDNA clone MGC:168483 IMAGE:9020860), complete cds.
AB529278 - Synthetic construct DNA, clone: pF1KE0858, Homo sapiens OR10H5 gene for olfactory receptor, family 10, subfamily H, member 5, without stop codon, in Flexi system.
JD249168 - Sequence 230192 from Patent EP1572962.
JD255365 - Sequence 236389 from Patent EP1572962.
LQ741780 - Sequence 28 from Patent WO2018087285.
JD057455 - Sequence 38479 from Patent EP1572962.
JD158012 - Sequence 139036 from Patent EP1572962.
JD443895 - Sequence 424919 from Patent EP1572962.
JD164217 - Sequence 145241 from Patent EP1572962.
JD230206 - Sequence 211230 from Patent EP1572962.
JD375079 - Sequence 356103 from Patent EP1572962.
JD550067 - Sequence 531091 from Patent EP1572962.
JD325249 - Sequence 306273 from Patent EP1572962.
JD408909 - Sequence 389933 from Patent EP1572962.
JD231789 - Sequence 212813 from Patent EP1572962.
LQ741784 - Sequence 32 from Patent WO2018087285.
JD528110 - Sequence 509134 from Patent EP1572962.
LQ741783 - Sequence 31 from Patent WO2018087285.
LQ741782 - Sequence 30 from Patent WO2018087285.
JD246398 - Sequence 227422 from Patent EP1572962.
JD487685 - Sequence 468709 from Patent EP1572962.
JD085037 - Sequence 66061 from Patent EP1572962.
JD045894 - Sequence 26918 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04740 - Olfactory transduction

Reactome (by CSHL, EBI, and GO)

Protein Q8NGA6 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001004466, NP_001004466, O10H5_HUMAN, Q6IFJ0, Q8NGA6, Q96R60
UCSC ID: uc010xos.2
RefSeq Accession: NM_001004466
Protein: Q8NGA6 (aka O10H5_HUMAN or OAH5_HUMAN)
CCDS: CCDS32940.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001004466.1
exon count: 1CDS single in 3' UTR: no RNA size: 948
ORF size: 948CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1996.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.