Human Gene CSAG2 (uc004ffs.3) Description and Page Index
  Description: Homo sapiens CSAG family, member 2 (CSAG2), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:151,876,743-151,877,747 Size: 1,005 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chrX:151,877,053-151,877,594 Size: 542 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:151,876,743-151,877,747)mRNA (may differ from genome)Protein (127 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblExonPrimerGeneCardsGeneNetworkH-INVHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE
TreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CSAG2_HUMAN
DESCRIPTION: RecName: Full=Chondrosarcoma-associated gene 2/3 protein; AltName: Full=Cancer/testis antigen 24.2; Short=CT24.2; AltName: Full=Taxol-resistant-associated gene 3 protein; Short=TRAG-3;
FUNCTION: Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.
TISSUE SPECIFICITY: Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435(TR) and the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR(10)V.

-  MalaCards Disease Associations
  MalaCards Gene Search: CSAG2
Diseases sorted by gene-association score: chondrosarcoma (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.08 RPKM in Testis
Total median expression: 0.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.50153-0.265 Picture PostScript Text
3' UTR -86.28310-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9Y5P2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0042493 response to drug


-  Descriptions from all associated GenBank mRNAs
  KJ896338 - Synthetic construct Homo sapiens clone ccsbBroadEn_05732 CSAG2 gene, encodes complete protein.
AF268420 - Homo sapiens chondrosarcoma CSAG2a mRNA sequence.
AF268421 - Homo sapiens chondrosarcoma CSAG2b mRNA sequence.
BC007228 - Homo sapiens CSAG family, member 3, mRNA (cDNA clone IMAGE:2819959), complete cds.
AF080246 - Homo sapiens taxol resistant associated protein (TRAG3) mRNA, complete cds.
AF136715 - Homo sapiens taxol resistant associated protein (TRAG-3L) mRNA, complete cds.
AJ844639 - Homo sapiens partial mRNA for taxol resistance associated gene 3 (CSAG2 gene).
BC119734 - Homo sapiens CSAG family, member 3, mRNA (cDNA clone MGC:149851 IMAGE:40119148), complete cds.
BC119735 - Homo sapiens CSAG family, member 3, mRNA (cDNA clone MGC:149852 IMAGE:40119150), complete cds.
JD258741 - Sequence 239765 from Patent EP1572962.
JD040285 - Sequence 21309 from Patent EP1572962.
JD146208 - Sequence 127232 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CSAG2_HUMAN, CSAG3, CSAG3A, NM_001080848, NP_001074317, O75605, Q0VDC3, Q96IU8, Q9Y5P2, TRAG3
UCSC ID: uc004ffs.3
RefSeq Accession: NM_001080848
Protein: Q9Y5P2 (aka CSAG2_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001080848.2
exon count: 2CDS single in 3' UTR: no RNA size: 847
ORF size: 384CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 728.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 265# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.